Fenclonine hydrochloride (Synonyms: 4-Chloro-DL-phenylalanine hydrochloride; PCPA hydrochloride; CP-10188 hydrochloride)

Name: Fenclonine hydrochloride
Brand: MedChemExpress
SKU: HY-W772850
Rating: 5.0 (23 reviews)

Cat. No.: HY-W772850 Purity: 98.60%: Data Sheet
COA

SDS
Handling Instructions
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Fenclonine hydrochloride is a selective and irreversible tryptophan hydroxylase inhibitor, which is a rate-limiting enzyme in the biosynthesis of serotonin. Fenclonine hydrochloride can be used in carcinoid syndrome research.

For research use only. We do not sell to patients.

CAS No. : 23633-07-0

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
250 mg	In-stock	Estimated Time of Arrival: December 31
500 mg	In-stock	Estimated Time of Arrival: December 31
1 g	In-stock	Estimated Time of Arrival: December 31
5 g	Get quote
10 g	Get quote

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Customer Review

Based on 23 publication(s) in Google Scholar

Other Forms of Fenclonine hydrochloride:

Fenclonine In-stock

23 Publications Citing Use of MCE Fenclonine hydrochloride

Cell Imaging/Staining

In Vivo Efficacy Study

: Fenclonine hydrochloride purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Mar 26:e2405850. [Abstract]; Fenclonine (PCPA; 0.05, 0.1, 0.5, 1 μM; 24 h) at 0.5 µm effectively reduced the hair cell injury caused by neomycin in the basal and middle turns of the cultured explants. Immunostaining of hair cells with Myosin 7a in cultured explants.

: Fenclonine hydrochloride purchased from MedChemExpress. Usage Cited in: EMBO Rep. 2024 Feb;25(2):570-592. [Abstract]; Fenclonine (pCPA; 2 mg/L; 72 h) treatment 2-mpf WT and nomo1 deficiency zebrafish significantly rescued the overactive locomotor behavior of nomo1_−/−.

: Fenclonine hydrochloride purchased from MedChemExpress. Usage Cited in: J Proteome Res. 2023 Sep 1;22(9):2936-2949. [Abstract]; Fenclonine (PCPA; 300 mg/kg; IP; once a day between 8:00 and 9:00 a.m. for 2 consecutive days) in Eight week old male C57BL/6J mice presented a significant decrease in spontaneous alternation in the Y-maze test (Figure 1B), whereas no difference in total arm entries (Figure 1C). For the NOR test, the recognition index of PCPA mice was significantly reduced (Figure 1D), demonstrating an impaired cognitive function.

: Fenclonine hydrochloride purchased from MedChemExpress. Usage Cited in: J Proteome Res. 2023 Sep 1;22(9):2936-2949. [Abstract]; Fenclonine (PCPA; 300 mg/kg; IP; once a day between 8:00 and 9:00 a.m. for 2 consecutive days; saline plus diazepam group and PCPA plus diazepam group received an intragastrical administration of diazepam (3 mg/kg) 26–28 h after the first PCPA injection for 2 consecutive days) in Eight week old male C57BL/6J mice showd Ptn expression in the PCPA plus diazepam group was significantly upregulated in the dentate gyrus (DG) in the hippocampus. Western blots showing Ptn expression in the hippocampus from saline, PCPA + saline, PCPA + diazepam, and saline + diazepam-treated mice.

: Fenclonine hydrochloride purchased from MedChemExpress. Usage Cited in: J Proteome Res. 2023 Sep 1;22(9):2936-2949. [Abstract]; Fenclonine (PCPA; 300 mg/kg; IP; once a day between 8:00 and 9:00 a.m. for 2 consecutive days; saline plus diazepam group and PCPA plus diazepam group received an intragastrical administration of diazepam (3 mg/kg) 26–28 h after the first PCPA injection for 2 consecutive days) in Eight week old male C57BL/6J mice showd Ptn expression in the PCPA plus diazepam group was significantly upregulated in the dentate gyrus (DG) in the hippocampus. Representative confocal images of Ptn (red) and DAPI (blue) expression in the hippocampus from saline + saline, PCPA + saline, PCPA + diazepam, and saline + diazepam-treated mice.

: Fenclonine hydrochloride purchased from MedChemExpress. Usage Cited in: J Proteome Res. 2023 Sep 1;22(9):2936-2949. [Abstract]; Fenclonine (PCPA; 300 mg/kg; IP; once a day between 8:00 and 9:00 a.m. for 2 consecutive days; saline plus diazepam group and PCPA plus diazepam group received an intragastrical administration of diazepam (3 mg/kg) 26–28 h after the first PCPA injection for 2 consecutive days) in Eight week old male C57BL/6J mice showd a significant increase in the rate of TUNEL-positive cells in the PCPA group, indicating the neuronal apoptosis. Representative confocal images of NeuN (red)-TUNEL (green) and DAPI (blue) expression in the hippocampus from control and PCPA groups.

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Description

Molecular Weight

236.10

Formula

C₉H₁₁Cl₂NO₂

CAS No.

23633-07-0

Appearance

Solid

Color

White to off-white

SMILES

O=C(C(CC1=CC=C(C=C1)Cl)N)O.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 116.67 mg/mL (494.16 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.2355 mL	21.1775 mL	42.3549 mL
5 mM	0.8471 mL	4.2355 mL	8.4710 mL
10 mM	0.4235 mL	2.1177 mL	4.2355 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 5 mg/mL (21.18 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 5 mg/mL (21.18 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 5 mg/mL (21.18 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 98.60%

Select Batch:

Data Sheet (273 KB) SDS (393 KB)

COA (246 KB) HNMR (222 KB) LCMS (94 KB)

Handling Instructions (2659 KB)

References

[1]. M Jouvet. Sleep and serotonin: an unfinished story. Neuropsychopharmacology. 1999 Aug;21(2 Suppl):24S-27S. [Content Brief]

[2]. A K Sanyal, et al. Prostaglandins: antinociceptive effect of prostaglandin E1 in the rat. Clin Exp Pharmacol Physiol. 1977 May-Jun;4(3):247-55. [Content Brief]

[3]. Shyamshree S S Manna, et al. Paracetamol potentiates the antidepressant-like and anticompulsive-like effects of fluoxetine. Behav Pharmacol. 2015 Apr;26(3):268-81. [Content Brief]

[4]. Zheng Y, et al. In silico Analysis and Experimental Validation of Lignan Extracts from Kadsura longipedunculata for Potential 5-HT1AR Agonists. PLoS One. 2015 Jun 15;10(6):e0130055. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.2355 mL	21.1775 mL	42.3549 mL	105.8873 mL
	5 mM	0.8471 mL	4.2355 mL	8.4710 mL	21.1775 mL
	10 mM	0.4235 mL	2.1177 mL	4.2355 mL	10.5887 mL
	15 mM	0.2824 mL	1.4118 mL	2.8237 mL	7.0592 mL
	20 mM	0.2118 mL	1.0589 mL	2.1177 mL	5.2944 mL
	25 mM	0.1694 mL	0.8471 mL	1.6942 mL	4.2355 mL
	30 mM	0.1412 mL	0.7059 mL	1.4118 mL	3.5296 mL
	40 mM	0.1059 mL	0.5294 mL	1.0589 mL	2.6472 mL
	50 mM	0.0847 mL	0.4235 mL	0.8471 mL	2.1177 mL
	60 mM	0.0706 mL	0.3530 mL	0.7059 mL	1.7648 mL
	80 mM	0.0529 mL	0.2647 mL	0.5294 mL	1.3236 mL
	100 mM	0.0424 mL	0.2118 mL	0.4235 mL	1.0589 mL

Fenclonine hydrochloride Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fenclonine23633-07-04-Chloro-DL-phenylalaninePCPACP-10188CP10188CP 10188Tryptophan Hydroxylaseselectiveirreversibleserotonincarcinoid syndromeInhibitorinhibitorinhibit

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Fenclonine hydrochloride (Synonyms: 4-Chloro-DL-phenylalanine hydrochloride; PCPA hydrochloride; CP-10188 hydrochloride)

Customer Review

Other Forms of Fenclonine hydrochloride:

Fenclonine hydrochloride Related Antibodies

23 Publications Citing Use of MCE Fenclonine hydrochloride

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity

Purity & Documentation

References

Customer Review

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

Fenclonine hydrochloride Related Classifications

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Your Recently Viewed Products:

Customer Review

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