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Fenclonine

(Synonyms: 4-Chloro-DL-phenylalanine; PCPA; CP-10188)
25 Cited Publications
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Based on 25 publication(s) in Google Scholar

Fenclonine is a selective and irreversible tryptophan hydroxylase inhibitor, which is a rate-limiting enzyme in the biosynthesis of serotonin. Fenclonine can be used in carcinoid syndrome research.

For research use only. We do not sell to patients.

  • Purity: 99.98%
  • CAS No.: 7424-00-2
  • Formula: C9H10ClNO2
  • Molecular Weight:199.64
  • Storage:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 2 years , -20°C, 1 year
  • Fenclonine Chemical Structure
    Fenclonine Chemical Structure
  • Experimental Validation Results for Fenclonine
  • Experimental Validation Results for Fenclonine
  • Experimental Validation Results for Fenclonine
  • Experimental Validation Results for Fenclonine
  • Experimental Validation Results for Fenclonine
  • Experimental Validation Results for Fenclonine
CAS No.: 7424-00-2
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Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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  • Fenclonine Chemical Structure
    Fenclonine Chemical Structure
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    Fenclonine purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Mar 26:e2405850. [Abstract]

    Customer Validation
     Fenclonine (PCPA; 0.05, 0.1, 0.5, 1 μM; 24 h) at 0.5 µm effectively reduced the hair cell injury caused by neomycin in the basal and middle turns of the cultured explants. Immunostaining of hair cells with Myosin 7a in cultured explants.

  • 1/16

    Fenclonine purchased from MedChemExpress. Usage Cited in: EMBO Rep. 2024 Feb;25(2):570-592. [Abstract]

    Customer Validation
     Fenclonine (pCPA; 2 mg/L; 72 h) treatment 2-mpf WT and nomo1 deficiency zebrafish significantly rescued the overactive locomotor behavior of nomo1−/−.

  • 1/16

    Fenclonine purchased from MedChemExpress. Usage Cited in: J Proteome Res. 2023 Sep 1;22(9):2936-2949. [Abstract]

    Customer Validation
     Fenclonine (PCPA; 300 mg/kg; IP; once a day between 8:00 and 9:00 a.m. for 2 consecutive days) in Eight week old male C57BL/6J mice presented a significant decrease in spontaneous alternation in the Y-maze test (Figure 1B), whereas no difference in total arm entries (Figure 1C). For the NOR test, the recognition index of PCPA mice was significantly reduced (Figure 1D), demonstrating an impaired cognitive function.

  • 1/16

    Fenclonine purchased from MedChemExpress. Usage Cited in: J Proteome Res. 2023 Sep 1;22(9):2936-2949. [Abstract]

    Customer Validation
     Fenclonine (PCPA; 300 mg/kg; IP; once a day between 8:00 and 9:00 a.m. for 2 consecutive days; saline plus diazepam group and PCPA plus diazepam group received an intragastrical administration of diazepam (3 mg/kg) 26–28 h after the first PCPA injection for 2 consecutive days) in Eight week old male C57BL/6J mice showd Ptn expression in the PCPA plus diazepam group was significantly upregulated in the dentate gyrus (DG) in the hippocampus. Western blots showing Ptn expression in the hippocampus from saline, PCPA + saline, PCPA + diazepam, and saline + diazepam-treated mice.

  • 1/16

    Fenclonine purchased from MedChemExpress. Usage Cited in: J Proteome Res. 2023 Sep 1;22(9):2936-2949. [Abstract]

    Customer Validation
     Fenclonine (PCPA; 300 mg/kg; IP; once a day between 8:00 and 9:00 a.m. for 2 consecutive days; saline plus diazepam group and PCPA plus diazepam group received an intragastrical administration of diazepam (3 mg/kg) 26–28 h after the first PCPA injection for 2 consecutive days) in Eight week old male C57BL/6J mice showd Ptn expression in the PCPA plus diazepam group was significantly upregulated in the dentate gyrus (DG) in the hippocampus. Representative confocal images of Ptn (red) and DAPI (blue) expression in the hippocampus from saline + saline, PCPA + saline, PCPA + diazepam, and saline + diazepam-treated mice.

  • 1/16

    Fenclonine purchased from MedChemExpress. Usage Cited in: J Proteome Res. 2023 Sep 1;22(9):2936-2949. [Abstract]

    Customer Validation
     Fenclonine (PCPA; 300 mg/kg; IP; once a day between 8:00 and 9:00 a.m. for 2 consecutive days; saline plus diazepam group and PCPA plus diazepam group received an intragastrical administration of diazepam (3 mg/kg) 26–28 h after the first PCPA injection for 2 consecutive days) in Eight week old male C57BL/6J mice showd a significant increase in the rate of TUNEL-positive cells in the PCPA group, indicating the neuronal apoptosis. Representative confocal images of NeuN (red)-TUNEL (green) and DAPI (blue) expression in the hippocampus from control and PCPA groups.

  • Fenclonine