AGN-2979 hydrochloride
AGN‑2979 hydrochloride (SC 48274 hydrochloride; BTG 1501 hydrochloride) is an orally active and selective tryptophan hydroxylase inhibitor with antidepressant-like and anxiolytic-like activities. AGN‑2979 hydrochloride inhibits stress-induced activation of tryptophan hydroxylase, thereby limiting the biosynthesis of 5-hydroxytryptamine in the brain. AGN-2979 hydrochloride possesses non-sedative anxiolytic and cognitive-enhancing properties. AGN-2979 hydrochloride is applicable to research related to depression and generalized anxiety disorder.
For research use only. We do not sell to patients.
- CAS No.: 103353-87-3
- Formula: C19H29ClN2O3
- Molecular Weight:368.90
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vivo
AGN‑2979 induces transient behavioral changes characterized by sedation and hypoactivity in both stressed and control Wistar rats, and these abnormal behaviors disappear after 3 weeks of administration[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 103353-87-3
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Molecular Weight 368.90
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Formula C19H29ClN2O3
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SMILES
O=C(C(C1=CC=CC(OC)=C1)(CCCN(C)C)C(C)(C)C2)NC2=O.Cl
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Synonyms
SC 48274 hydrochloride; BTG 1501 hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Gittos MW, et al. Antidepressant-like action of AGN 2979, a tryptophan hydroxylase activation inhibitor, in a chronic mild stress model of depression in rats. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 2001 Oct;11(5):351-7. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AGN-2979 hydrochloride Related Classifications
HY-19046 Related Classifications
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Keywords
- AGN-2979
- 103353-87-3
- SC 48274
- BTG 1501
- AGN2979
- AGN 2979
- SC48274
- SC-48274
- BTG1501
- BTG-1501
- Tryptophan Hydroxylase
- generalized anxiety disorder
- antidepressant-like activity
- monoaminergic neurotransmission reuptake
- muscarinic ligands
- non-sedating anxiolytic
- neuronal K+ channel
- depression
- tryptophan hydroxylase
- cognitive enhancing properties
- Inhibitor
- inhibitor
- inhibit