1. Metabolic Enzyme/Protease Neuronal Signaling GPCR/G Protein
  2. Tryptophan Hydroxylase 5-HT Receptor
  3. PCPA methyl ester hydrochloride

PCPA methyl ester hydrochloride  (Synonyms: 4-Chloro-DL-phenylalanine methyl ester hydrochloride)

Cat. No.: HY-101456 Purity: 99.89%
COA Handling Instructions

PCPA methyl ester hydrochloride (4-Chloro-DL-phenylalanine methyl ester hydrochloride), a reversible tryptophan hydroxylase inhibitor, is a serotonin (5-HT) synthesis inhibitor. PCPA methyl ester hydrochloride crosses the blood brain barrier and reduces 5-HT central availability.

For research use only. We do not sell to patients.

PCPA methyl ester hydrochloride Chemical Structure

PCPA methyl ester hydrochloride Chemical Structure

CAS No. : 14173-40-1

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Based on 2 publication(s) in Google Scholar

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2 Publications Citing Use of MCE PCPA methyl ester hydrochloride

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Description

PCPA methyl ester hydrochloride (4-Chloro-DL-phenylalanine methyl ester hydrochloride), a reversible tryptophan hydroxylase inhibitor, is a serotonin (5-HT) synthesis inhibitor. PCPA methyl ester hydrochloride crosses the blood brain barrier and reduces 5-HT central availability[1][2].

IC50 & Target[1][2]

serotonin

 

Tryptophan Hydroxylase

 

In Vivo

PCPA methyl ester hydrochloride (250-500 mg/kg; oral administration; daily; for 8 weeks) treatment significantly decreases serotonin levels in both hippocampus and cortex[3].
In C57BL/6 elite male mice, 5-HT levels decreased by 85% and 55% in the hippocampus of mice treated with oral or ip PCPA methyl ester hydrochloride, respectively, whereas in the prefrontal cortex, 5-HT levels decreased by 65% (oral) and 50% (ip)[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 elite male mice (3 months old)[3]
Dosage: 500 mg/kg per day for the first 2 days and 250 mg/kg for the rest of the treatment
Administration: Oral administration; daily; for 8 weeks
Result: Serotonin levels were significantly decreased in both hippocampus and cortex.
Molecular Weight

250.12

Formula

C10H13Cl2NO2

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

NC(CC1=CC=C(Cl)C=C1)C(OC)=O.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (199.90 mM; Need ultrasonic)

H2O : 50 mg/mL (199.90 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.9981 mL 19.9904 mL 39.9808 mL
5 mM 0.7996 mL 3.9981 mL 7.9962 mL
10 mM 0.3998 mL 1.9990 mL 3.9981 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (399.81 mM); Clear solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 5 mg/mL (19.99 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 5 mg/mL (19.99 mM); Clear solution

  • 4.

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 5 mg/mL (19.99 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation

Purity: 99.89%

References
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PCPA methyl ester hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
PCPA methyl ester hydrochloride
Cat. No.:
HY-101456
Quantity:
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