1. Metabolic Enzyme/Protease
    Neuronal Signaling
    GPCR/G Protein
  2. Tryptophan Hydroxylase
    5-HT Receptor
  3. PCPA methyl ester hydrochloride

PCPA methyl ester hydrochloride (Synonyms: 4-Chloro-DL-phenylalanine methyl ester hydrochloride)

Cat. No.: HY-101456
Handling Instructions

PCPA methyl ester hydrochloride (4-Chloro-DL-phenylalanine methyl ester hydrochloride), a reversible tryptophan hydroxylase inhibitor, is a serotonin (5-HT) synthesis inhibitor. PCPA methyl ester hydrochloride crosses the blood brain barrier and reduces 5-HT central availability.

For research use only. We do not sell to patients.

PCPA methyl ester hydrochloride Chemical Structure

PCPA methyl ester hydrochloride Chemical Structure

CAS No. : 14173-40-1

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Description

PCPA methyl ester hydrochloride (4-Chloro-DL-phenylalanine methyl ester hydrochloride), a reversible tryptophan hydroxylase inhibitor, is a serotonin (5-HT) synthesis inhibitor. PCPA methyl ester hydrochloride crosses the blood brain barrier and reduces 5-HT central availability[1][2].

IC50 & Target[1][2]

serotonin

 

Tryptophan Hydroxylase

 

In Vivo

PCPA methyl ester hydrochloride (250-500 mg/kg; oral administration; daily; for 8 weeks) treatment significantly decreases serotonin levels in both hippocampus and cortex[3].
In C57BL/6 elite male mice, 5-HT levels decreased by 85% and 55% in the hippocampus of mice treated with oral or ip PCPA methyl ester hydrochloride, respectively, whereas in the prefrontal cortex, 5-HT levels decreased by 65% (oral) and 50% (ip)[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 elite male mice (3 months old)[3]
Dosage: 500 mg/kg per day for the first 2 days and 250 mg/kg for the rest of the treatment
Administration: Oral administration; daily; for 8 weeks
Result: Serotonin levels were significantly decreased in both hippocampus and cortex.
Molecular Weight

250.12

Formula

C₁₀H₁₃Cl₂NO₂

CAS No.

14173-40-1

SMILES

NC(CC1=CC=C(Cl)C=C1)C(OC)=O.Cl

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

PCPA methyl ester4-Chloro-DL-phenylalanine methyl esterTryptophan Hydroxylase5-HT ReceptorSerotonin Receptor5-hydroxytryptamine Receptorinsomniareversible5-HTBBBInhibitorinhibitorinhibit

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Product Name:
PCPA methyl ester hydrochloride
Cat. No.:
HY-101456
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