18771-50-1
18771-50-1
Chemical Structure
Tetrahydrouridine
Synonym(s): THU; NSC-112907
- CAS No.: 18771-50-1
- Formula:C9H16N2O6
- Molecular Weight:248.23
IUPAC Name: 1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-hydroxytetrahydropyrimidin-2(1H)-one
InChIKey: UCKYOOZPSJFJIZ-XVKVHKPRSA-N
SMILES: O=C1N([C@H]2[C@H](O)[C@H](O)[C@@H](CO)O2)CCC(O)N1
Biological Activity: Tetrahydrouridine dihydrate is potent inhibitor of cytidine deaminase (CDA), which competitively blocks the enzyme's active site more effectively than intrinsic cytidine[1][2].
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Tetrahydrouridine | 99.91% | Tetrahydrouridine dihydrate is potent inhibitor of cytidine deaminase (CDA), which competitively blocks the enzyme's active site more effectively than intrinsic cytidine. | ||||||||||||||||||||
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Tetrahydrouridine-d3 | Tetrahydrouridine-d3 is the deuterium labeled Tetrahydrouridine. Tetrahydrouridine dihydrate is potent inhibitor of cytidine deaminase (CDA), which competitively blocks the enzyme's active site more effectively than intrinsic cytidine. | |||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.81
HY-113047R5,6-Dihydrouridine (Standard) -
Similarity Score 0.81
HY-1523855,6-Dihydro-ara-uridine -
Similarity Score 0.77
HY-1308035-Methyl-5,6-dihydrouridine -
Similarity Score 0.71
HY-109081Cedazuridine -
Similarity Score 0.70
HY-106689Dihydro-5-azacytidine -
Similarity Score 0.68
HY-106689ADihydro-5-azacytidine acetate -
Similarity Score 0.66
HY-130806Dihydrodeoxyuridine -
Similarity Score 0.65
HY-1308075,6-Dihydrothymidine -
Similarity Score 0.63
HY-W984166Antibiotic U 44590 -
Explore the MedChemAI to find more analogs
References
- [1]. Funamizu N, et al. Tetrahydrouridine inhibits cell proliferation through cell cycle regulation regardless of cytidine deaminase expression levels. PLoS One. 2012;7(5):e37424. [Content Brief]
- [2]. Terse P, et al. Subchronic oral toxicity study of decitabine in combination with tetrahydrouridine in CD-1 mice. Int J Toxicol. 2014 Mar-Apr;33(2):75-85. [Content Brief]
