18771-50-1
18771-50-1
Chemical Structure
Tetrahydrouridine
Synonym(s): THU; NSC-112907
- CAS No.: 18771-50-1
- Formula:C9H16N2O6
- Molecular Weight:248.23
IUPAC Name: 1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-hydroxytetrahydropyrimidin-2(1H)-one
InChIKey: UCKYOOZPSJFJIZ-XVKVHKPRSA-N
SMILES: O=C1N([C@H]2[C@H](O)[C@H](O)[C@@H](CO)O2)CCC(O)N1
Biological Activity: Tetrahydrouridine dihydrate is potent inhibitor of cytidine deaminase (CDA), which competitively blocks the enzyme's active site more effectively than intrinsic cytidine[1][2].
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Tetrahydrouridine | 99.91% | Tetrahydrouridine dihydrate is potent inhibitor of cytidine deaminase (CDA), which competitively blocks the enzyme's active site more effectively than intrinsic cytidine. | ||||||||||||||||||||
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Tetrahydrouridine (Standard) | ≥98% | Tetrahydrouridine (Standard) is the analytical standard of Tetrahydrouridine. This product is intended for research and analytical applications. Tetrahydrouridine dihydrate is potent inhibitor of cytidine deaminase (CDA), which competitively blocks the enzyme's active site more effectively than intrinsic cytidine. | ||||||||||||||||||||
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Tetrahydrouridine-d3 | Tetrahydrouridine-d3 is the deuterium labeled Tetrahydrouridine. Tetrahydrouridine dihydrate is potent inhibitor of cytidine deaminase (CDA), which competitively blocks the enzyme's active site more effectively than intrinsic cytidine. | |||||||||||||||||||||
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References
- [1]. Funamizu N, et al. Tetrahydrouridine inhibits cell proliferation through cell cycle regulation regardless of cytidine deaminase expression levels. PLoS One. 2012;7(5):e37424. [Content Brief]
- [2]. Terse P, et al. Subchronic oral toxicity study of decitabine in combination with tetrahydrouridine in CD-1 mice. Int J Toxicol. 2014 Mar-Apr;33(2):75-85. [Content Brief]
