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Dehydroepiandrosterone sulfate (Synonyms: DHEA sulfate; Prasterone sulfate)

Cat. No.: HY-113416
Handling Instructions

Dehydroepiandrosterone sulfate, a neuroactive neurosteroid, plays a major role in brain development and aging by influencing the migration of neurons, arborization of dendrites, and formation of new synapses.

For research use only. We do not sell to patients.

Dehydroepiandrosterone sulfate Chemical Structure

Dehydroepiandrosterone sulfate Chemical Structure

CAS No. : 651-48-9

Size Price Stock Quantity
5 mg USD 110 In-stock
Estimated Time of Arrival: December 31
10 mg USD 180 In-stock
Estimated Time of Arrival: December 31
25 mg USD 360 In-stock
Estimated Time of Arrival: December 31
50 mg USD 570 In-stock
Estimated Time of Arrival: December 31
100 mg USD 850 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Dehydroepiandrosterone sulfate, a neuroactive neurosteroid, plays a major role in brain development and aging by influencing the migration of neurons, arborization of dendrites, and formation of new synapses[1][2][3].

In Vitro

Dehydroepiandrosterone sulfate (DHEAS) selectively increased the length of neurites containing the dendritic marker MAP-2[1].
Dehydroepiandrosterone sulfate (DHEAS) has been reported to increase neuronal excitability (firing rate) when directly applied to septal-preoptic neurons[1].
Dehydroepiandrosterone (DHEA) is produced in prodigious quantities by the human adrenal, principally as the 3-sulfoconjugate DHEA sulfate (DS) during intrauterine life[2].
Dehydroepiandrosterone sulfate (DHEAS) is generally nontoxic and lacks adverse side effects even when it is administered chronically[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

DHEAS chronic administration produces a dose-dependent effect on performance[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sixty-four male Sprague-Dawley rats, approximately 90 days of age (300-400 g)[3].
Dosage: 5, 10, or 20 mg/kg.
Administration: Subcutaneous injection starting 7 days post-surgery and 1 h prior to all behavioral testing.
Result: Significantly effective in improving latency to reach the platform as compared to injured rats receiving vehicle.
Molecular Weight

368.49

Formula

C₁₉H₂₈O₅S

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (271.38 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7138 mL 13.5689 mL 27.1378 mL
5 mM 0.5428 mL 2.7138 mL 5.4276 mL
10 mM 0.2714 mL 1.3569 mL 2.7138 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.78 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.78 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
Dehydroepiandrosterone sulfate
Cat. No.:
HY-113416
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