1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. Creatinine

Creatinine  (Synonyms: NSC13123)

Cat. No.: HY-B0504 Purity: 99.67%
COA Handling Instructions

Creatinine(NSC13123) is a break-down product of creatine phosphate in muscle, and is usually produced at a fairly constant rate by the body.

For research use only. We do not sell to patients.

Creatinine Chemical Structure

Creatinine Chemical Structure

CAS No. : 60-27-5

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Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
10 mM * 1 mL in DMSO USD 55 In-stock
Solid
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1 g USD 60 In-stock
5 g USD 72 In-stock
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Customer Review

Based on 2 publication(s) in Google Scholar

Other Forms of Creatinine:

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  • Biological Activity

  • Purity & Documentation

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Description

Creatinine(NSC13123) is a break-down product of creatine phosphate in muscle, and is usually produced at a fairly constant rate by the body. Target: Others Creatinine is a breakdown product of creatine phosphate in muscle, and is usually produced at a fairly constant rate by the body (depending on muscle mass). Creatine is synthesized primarily in the liver from the methylation of glycocyamine (guanidino acetate, synthesized in the kidney from the amino acids arginine and glycine) by S-adenosyl methionine. It is then transported through blood to the other organs, muscle, and brain, where, through phosphorylation, it becomes the high-energy compound phosphocreatine. During the reaction, creatine and phosphocreatine are catalyzed by creatine kinase, and a spontaneous conversion to creatinine may occur [1]. Creatinine levels in blood and urine may be used to calculate the creatinine clearance (CrCl), which reflects the glomerular filtration rate (GFR), an important clinical index of renal function [2].

IC50 & Target

Microbial Metabolite

 

Human Endogenous Metabolite

 

Clinical Trial
Molecular Weight

113.12

Formula

C4H7N3O

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1N=C(N)N(C)C1

Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

H2O : 33.33 mg/mL (294.64 mM; Need ultrasonic)

DMSO : 2.5 mg/mL (22.10 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 8.8402 mL 44.2008 mL 88.4017 mL
5 mM 1.7680 mL 8.8402 mL 17.6803 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 33.33 mg/mL (294.64 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 8.8402 mL 44.2008 mL 88.4017 mL 221.0042 mL
5 mM 1.7680 mL 8.8402 mL 17.6803 mL 44.2008 mL
10 mM 0.8840 mL 4.4201 mL 8.8402 mL 22.1004 mL
15 mM 0.5893 mL 2.9467 mL 5.8934 mL 14.7336 mL
20 mM 0.4420 mL 2.2100 mL 4.4201 mL 11.0502 mL
H2O 25 mM 0.3536 mL 1.7680 mL 3.5361 mL 8.8402 mL
30 mM 0.2947 mL 1.4734 mL 2.9467 mL 7.3668 mL
40 mM 0.2210 mL 1.1050 mL 2.2100 mL 5.5251 mL
50 mM 0.1768 mL 0.8840 mL 1.7680 mL 4.4201 mL
60 mM 0.1473 mL 0.7367 mL 1.4734 mL 3.6834 mL
80 mM 0.1105 mL 0.5525 mL 1.1050 mL 2.7626 mL
100 mM 0.0884 mL 0.4420 mL 0.8840 mL 2.2100 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Creatinine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Creatinine
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