130-26-7
Chemical Structure
Clioquinol
Synonym(s): Iodochlorohydroxyquinoline; Iodochlorhydroxyquin
- CAS No.: 130-26-7
- Formula:C9H5ClINO
- Molecular Weight:305.50
IUPAC Name: 5-chloro-7-iodoquinolin-8-ol
InChIKey: QCDFBFJGMNKBDO-UHFFFAOYSA-N
SMILES: ClC1=C(C=CC=N2)C2=C(O)C(I)=C1
Biological Activity: Clioquinol (Iodochlorhydroxyquin) is a topical antifungal agent with anticancer activity. Clioquinol acts as an oral antimicrobial agent for the research of diarrhea and skin infections. Antibiotic[1]. Clioquinol is a chelator that binds to Zn2+ and Cu2+ with a greater affinity than it binds to Ca2+ and Mg2+. Clioquinol freely crosses the blood-brain barrier. Clioquinol can be used for the study of Alzheimer's disease[2].
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Clioquinol | 99.84% | Clioquinol (Iodochlorhydroxyquin) is a topical antifungal agent with anticancer activity. Clioquinol acts as an oral antimicrobial agent for the research of diarrhea and skin infections. Antibiotic. Clioquinol is a chelator that binds to Zn2+ and Cu2+ with a greater affinity than it binds to Ca2+ and Mg2+. Clioquinol freely crosses the blood-brain barrier. Clioquinol can be used for the study of Alzheimer's disease. | ||||||||||||||||||||
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Clioquinol (Standard) | 98.01% | Clioquinol (Standard) is the analytical standard of Clioquinol. This product is intended for research and analytical applications. Clioquinol (Iodochlorhydroxyquin) is a topical antifungal agent with anticancer activity. Clioquinol acts as an oral antimicrobial agent for the research of diarrhea and skin infections. Antibiotic. | ||||||||||||||||||||
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Similarity Score 0.90
HY-B1400RDiiodohydroxyquinoline (Standard) -
Similarity Score 0.90
HY-B0295RChloroxine (Standard) -
Similarity Score 0.84
HY-B0963RCloxiquine (Standard) -
Similarity Score 0.84
HY-W2427094-Chloroquinolin-8-ol -
Similarity Score 0.81
HY-B1212Broxyquinoline -
Similarity Score 0.80
HY-15537Tilbroquinol -
Similarity Score 0.78
HY-W016535R7-Chloroquinolin-4-ol (Standard) -
Similarity Score 0.78
HY-B1360RChlorquinaldol (Standard) -
Similarity Score 0.76
HY-59243R4,7-Dichloroquinoline (Standard) -
Explore the MedChemAI to find more analogs
References
- [1]. Moe Wehbe, et al. Development of a copper-clioquinol formulation suitable for intravenous use. Drug Deliv Transl Res. 2018 Feb;8(1):239-251. [Content Brief]
- [2]. Regland B, et al. Treatment of Alzheimer's disease with clioquinol. Dement Geriatr Cogn Disord. 2001 Nov-Dec;12(6):408-14. [Content Brief]
