2. Anti-infection
    Autophagy
  3. Fungal
    Autophagy
    Mitophagy
    Antibiotic
    Parasite
  4. Clioquinol

Clioquinol  (Synonyms: Iodochlorohydroxyquinoline)

Cat. No.: HY-14603 Purity: 99.41%
COA Handling Instructions

Clioquinol (Iodochlorhydroxyquin) is a topical antifungal agent with anticancer activity. Clioquinol acts as an oral antimicrobial agent for the research of diarrhea and skin infections. Antibiotic.

For research use only. We do not sell to patients.

Clioquinol Chemical Structure

Clioquinol Chemical Structure

CAS No. : 130-26-7

Size Price Stock Quantity
Free Sample (0.1 - 0.5 mg)   Apply Now  
Solution
10 mM * 1 mL in DMSO USD 61 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 61 In-stock
Estimated Time of Arrival: December 31
Solid
500 mg USD 55 In-stock
Estimated Time of Arrival: December 31
1 g USD 66 In-stock
Estimated Time of Arrival: December 31
5 g USD 119 In-stock
Estimated Time of Arrival: December 31
10 g   Get quote  
50 g   Get quote  

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Customer Review

Based on 2 publication(s) in Google Scholar

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Clioquinol (Iodochlorhydroxyquin) is a topical antifungal agent with anticancer activity. Clioquinol acts as an oral antimicrobial agent for the research of diarrhea and skin infections. Antibiotic[1].

In Vitro

Clioquinol (0.01-1000 uM; 72 hours) shows anticancer activity against U251, and MV-4-11 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: The MV-4-11, and U-251 cell lines
Concentration: 0.01, 0.1, 1, 10, 100, 1000 uM
Incubation Time: 72 hours
Result: The IC50s were 32 and 46 μM in U251 and MV-4-11 cells, respectively.
Clinical Trial
Molecular Weight

305.50

Appearance

Solid

Formula

C9H5ClINO
CAS No.
SMILES

ClC1=C(C=CC=N2)C2=C(O)C(I)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 50 mg/mL (163.67 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2733 mL 16.3666 mL 32.7332 mL
5 mM 0.6547 mL 3.2733 mL 6.5466 mL
10 mM 0.3273 mL 1.6367 mL 3.2733 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 2.08 mg/mL (6.81 mM); Suspended solution; Need ultrasonic and warming

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (6.81 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.41%

COA (253 KB) HNMR (234 KB) LCMS (257 KB)

Handling Instructions (2659 KB)
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Clioquinol130-26-7IodochlorohydroxyquinolineFungalAutophagyMitophagyAntibioticParasiteMitochondrial AutophagyInhibitorinhibitorinhibit

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