Art. -Nr.: HY-14603

Clioquinol

Name: Clioquinol
Brand: MedChemExpress
SKU: HY-14603
Price: 55.00 USD
Availability: InStock
Rating: 5 (6 reviews)

(Synonyms: Iodochlorohydroxyquinoline)

6 Cited Publications

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Based on 6 publication(s) in Google Scholar

Clioquinol (Iodochlorhydroxyquin) is a topical antifungal agent with anticancer activity. Clioquinol acts as an oral antimicrobial agent for the research of diarrhea and skin infections. Antibiotic. Clioquinol is a chelator that binds to Zn²⁺ and Cu²⁺ with a greater affinity than it binds to Ca²⁺ and Mg²⁺. Clioquinol freely crosses the blood-brain barrier. Clioquinol can be used for the study of Alzheimer's disease.

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Reinheit : 99.84%
CAS. Nr.: 130-26-7
Formel: C₉H₅ClINO
Molecular Weight:305.50

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

Clioquinol Chemical Structure

CAS. Nr.: 130-26-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
- Clinical Trial
Chemical Information
Publications (6)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Protokoll (3)
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Clioquinol (Iodochlorhydroxyquin) is a topical antifungal agent with anticancer activity. Clioquinol acts as an oral antimicrobial agent for the research of diarrhea and skin infections. Antibiotic^[1]. Clioquinol is a chelator that binds to Zn²⁺ and Cu²⁺ with a greater affinity than it binds to Ca²⁺ and Mg²⁺. Clioquinol freely crosses the blood-brain barrier. Clioquinol can be used for the study of Alzheimer's disease^[2].

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Cellular Effect

Cell Line	Type	Value	Description	References
BV-2	EC₅₀	>30 μM Compound: CQ	Antineuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-stimulated NO production after 24 hrs by Griess assay Antineuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-stimulated NO production after 24 hrs by Griess assay	[PMID: 26473791]
Caco-2	IC₅₀	19.29 μg/mL Compound: Cq	Cytotoxicity against human Caco-2 cells assessed as cell growth inhibition incubated for 24 hrs by CCK8 assay Cytotoxicity against human Caco-2 cells assessed as cell growth inhibition incubated for 24 hrs by CCK8 assay	[PMID: 37975824]
PBMC	CC₅₀	2 μM Compound: 2, Clioquinol	Cytotoxicity against PBMC Cytotoxicity against PBMC	[PMID: 17000109]
SH-SY5Y	EC₅₀	>1 μM Compound: Clioquinol	Neuroprotective activity against t-BuOOH-induced oxidative stress in human SH-SY5Y cells assessed as inhibition ROS accumulation pre-incubated for 24 hrs before t-BuOOH challnge for 30 mins by DCFH-DA probe based fluorescence assay Neuroprotective activity against t-BuOOH-induced oxidative stress in human SH-SY5Y cells assessed as inhibition ROS accumulation pre-incubated for 24 hrs before t-BuOOH challnge for 30 mins by DCFH-DA probe based fluorescence assay	[PMID: 29420891]

In Vitro

Clioquinol (0.01-1000 uM; 72 hours) shows anticancer activity against U251, and MV-4-11 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Cell Viability Assay^[1]

View Protocol

Cell Line:

The MV-4-11, and U-251 cell lines
Concentration:

0.01, 0.1, 1, 10, 100, 1000 uM
Incubation Time:

72 hours
Result:

The IC₅₀s were 32 and 46 μM in U251 and MV-4-11 cells, respectively.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS. Nr. 130-26-7
Appearance Solid
Molecular Weight 305.50
Formel C₉H₅ClINO
Color Light yellow to brown
SMILES

ClC1=C(C=CC=N2)C2=C(O)C(I)=C1
Synonyms

Iodochlorohydroxyquinoline
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Publications (6)

All WBIn Vivo Efficacy StudyRT-PCRIFCell Proliferation/Viability Assay

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Journal Impact Factor

J Transl Med

Doxorubicin synergizes bortezomib-induced multiple myeloma cell death by inhibiting aggresome formation and augmenting endoplasmic reticulum/Golgi stress and apoptosis. [Abstract]

2024 Dec 3;22(1):1095. PMID: 39623468

Clioquinol purchased from MedChemExpress. Usage Cited in: J Transl Med. 2024 Dec 3;22(1):1095. [Abstract]

Clioquinol does not stimulate aggresome formation. U266B1 cells treated with no compound, 6.25 nM bortezomib, or 25 μΜ Clioquinol for 24 h, which resulted in ~ 30% cell death, were analyzed for aggresome formation by immunofluorescence. The percentage of cells with aggresomes was counted and plotted.

Clioquinol purchased from MedChemExpress. Usage Cited in: J Transl Med. 2024 Dec 3;22(1):1095. [Abstract]

Clioquinol does not synergize with Doxorubicin to enhance cell death. U266B1 cells treated with no chemical, 25 μΜ Clioquinol, or Clioquinol plus 1 μΜ doxorubicin for 24 h were analyzed for cell death using the trypan blue exclusion assay.
Oncogene

YTHDC2 inhibits the resistance of lung cancer to EGFR-TKI through cuproptosis. [Abstract]

2025 Dec 16. PMID: 41402633

Clioquinol purchased from MedChemExpress. Usage Cited in: Oncogene. 2025 Dec 16. [Abstract]

The protein expression of YTHDC2 and SLC31A1 in H1650 and H1975 cells after 8-hydroxyquinoline (HQ), clioquinol (CQ; 10 μM), and disulfiram (DSF) treatment by WB.
Anal Chem

Exposome-Scale Investigation of Cl-/Br-Containing Chemicals Using High-Resolution Mass Spectrometry, Multistage Machine Learning, and Cloud Computing. [Abstract]

2025 Jun 3;97(21):11099-11109. PMID: 40401576
Int Immunopharmacol

Mitophagy-mtROS axis contributes to anti-tuberculosis-induced liver injury through activation of the cGAS-STING pathway in rat hepatocytes. [Abstract]

2025 Jul 28:160:114984. PMID: 40449272
Am J Respir Cell Mol Biol

Clioquinol Attenuates Pulmonary Fibrosis through Inactivation of Fibroblasts via Iron Chelation. [Abstract]

2021 Aug;65(2):189-200. PMID: 33861690
Front Mol Neurosci

The Role of Transient Receptor Potential A1 and G Protein-Coupled Receptor 39 in Zinc-Mediated Acute and Chronic Itch in Mice. [Abstract]

2022 Jan 12:14:768731. PMID: 35095413

Clioquinol purchased from MedChemExpress. Usage Cited in: Front Mol Neurosci. 2022 Jan 12:14:768731. [Abstract]

Rotarod test was performed after i.p. injection of TPEN (10 mg/kg), pyrithione (10 mg/kg), and clioquinol (10 mg/kg).

Clioquinol purchased from MedChemExpress. Usage Cited in: Front Mol Neurosci. 2022 Jan 12:14:768731. [Abstract]

Zn2+ chelators pyrithione (5 mg/kg) and clioquinol (5 mg/kg) can decrease Trpa1 mRNA level, but not for TPEN (3 mg/kg) .

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : ≥ 50 mg/mL (163.67 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.2733 mL

16.3666 mL

32.7332 mL

5 mM

0.6547 mL

3.2733 mL

6.5466 mL

10 mM

0.3273 mL

1.6367 mL

3.2733 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: 2.08 mg/mL (6.81 mM); Suspended solution; Need ultrasonic and warming

This protocol yields a suspended solution of 2.08 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.08 mg/mL (6.81 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 50% PEG300 50% Saline

Solubility: 2 mg/mL (6.55 mM); Suspended solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Protokoll

All Signal Pathway Related Cell Biology Animals and Diseases

Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
Ca²⁺ Staining Technique
Ca²⁺ staining is an experimental technique that utilizes specific fluorescent probes (such as Fluo-4 AM, Fura-2, etc.) to qualitatively or quantitatively detect dynamic changes in intracellular Ca²⁺ concentrations; this is achieved by monitoring the changes in fluorescent signals generated when these probes bind to free intracellular calcium ions. The underlying principle relies primarily on the presence of chelating groups within the probe's molecular structure that possess high affinity for calcium ions.
Alzheimer’s Disease Modeling
Alzheimer’s Disease (AD) is a neurodegenerative disorder characterized by a progressive decline in cognitive functions and loss of specific types of neurons and synapses. Alzheimer's symptoms can be simulated in mice by injecting drugs (such as Aβ) or genetically modified.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (278 KB)
SDS (423 KB)
- English - EN (423 KB)
- Français - FR (423 KB)
- Deutsch - DE (423 KB)
- Norwegian - NO (423 KB)
- Español - ES (423 KB)
- Swedish - SV (423 KB)
- Italian - IT (423 KB)
- Korean - KR (423 KB)
- Portuguese - PT (423 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Moe Wehbe, et al. Development of a copper-clioquinol formulation suitable for intravenous use. Drug Deliv Transl Res. 2018 Feb;8(1):239-251. [Content Brief]

[2]. Regland B, et al. Treatment of Alzheimer's disease with clioquinol. Dement Geriatr Cogn Disord. 2001 Nov-Dec;12(6):408-14. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.2733 mL	16.3666 mL	32.7332 mL	81.8331 mL
	5 mM	0.6547 mL	3.2733 mL	6.5466 mL	16.3666 mL
	10 mM	0.3273 mL	1.6367 mL	3.2733 mL	8.1833 mL
	15 mM	0.2182 mL	1.0911 mL	2.1822 mL	5.4555 mL
	20 mM	0.1637 mL	0.8183 mL	1.6367 mL	4.0917 mL
	25 mM	0.1309 mL	0.6547 mL	1.3093 mL	3.2733 mL
	30 mM	0.1091 mL	0.5456 mL	1.0911 mL	2.7278 mL
	40 mM	0.0818 mL	0.4092 mL	0.8183 mL	2.0458 mL
	50 mM	0.0655 mL	0.3273 mL	0.6547 mL	1.6367 mL
	60 mM	0.0546 mL	0.2728 mL	0.5456 mL	1.3639 mL
	80 mM	0.0409 mL	0.2046 mL	0.4092 mL	1.0229 mL
	100 mM	0.0327 mL	0.1637 mL	0.3273 mL	0.8183 mL

Bioz

Keywords

Clioquinol

6 Cited Publications

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Clioquinol

Publications Citing Use of MedChemExpress (MCE) Clioquinol

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