321673-30-7
321673-30-7
Chemical Structure
BLT-1
Synonym(s): Block lipid transport-1
- CAS 番号: 321673-30-7
- Formula:C12H23N3S
- Molecular Weight:241.40
IUPAC Name: (Z)-2-(2-hexylcyclopentylidene)hydrazine-1-carbothioamide
InChIKey: OWGUSBISUVLUJF-KAMYIIQDSA-N
SMILES: CCCCCCC1CCC/C1=N/NC(N)=S
Biological Activity: BLT-1, a thiosemicarbazone copper chelator, is a selective scavenger receptor B, type 1 (SR-BI) inhibitor. BLT-1 inhibits the transfer of lipids between high-density lipoproteins (HDL) and cells mediated by SR-BI. BLT-1 is a potent HCV entry inhibitor[1][2][3][4].
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BLT-1 | 99.93% | BLT-1, a thiosemicarbazone copper chelator, is a selective scavenger receptor B, type 1 (SR-BI) inhibitor. BLT-1 inhibits the transfer of lipids between high-density lipoproteins (HDL) and cells mediated by SR-BI. BLT-1 is a potent HCV entry inhibitor. | ||||||||||||||||||||
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References
- [1]. Nieland TJ, et al. Discovery of chemical inhibitors of the selective transfer of lipids mediated by the HDL receptorSR-BI. Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15422-7. [Content Brief]
- [2]. Nieland TJ, et al. Identification of the molecular target of small molecule inhibitors of HDL receptor SR-BI activity. Biochemistry. 2008 Jan 8;47(1):460-72. [Content Brief]
- [3]. Raldúa D, et al. BLT-1, a specific inhibitor of the HDL receptor SR-BI, induces a copper-dependent phenotype during zebrafish development. Toxicol Lett. 2007 Dec 10;175(1-3):1-7. Epub 2007 Aug 22. [Content Brief]
- [4]. Hirofumi Ohashi, et al. Reply to Padmanabhan and Dixit: Hepatitis C virus entry inhibitors for optimally boosting direct-acting antiviral-based treatments. Proc Natl Acad Sci U S A. 2017 Jun 6;114(23):E4527-E4529. [Content Brief]
