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BLT-1 

Cat. No.: HY-116767
Handling Instructions

BLT-1, a thiosemicarbazone copper chelator, is a selective scavenger receptor B, type 1 (SR-BI) inhibitor. BLT-1 inhibits the transfer of lipids between high-density lipoproteins (HDL) and cells mediated by SR-BI. BLT-1 has pro-inflammatory functions through neutrophil recruitment.

For research use only. We do not sell to patients.

BLT-1 Chemical Structure

BLT-1 Chemical Structure

CAS No. : 321673-30-7

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Description

BLT-1, a thiosemicarbazone copper chelator, is a selective scavenger receptor B, type 1 (SR-BI) inhibitor. BLT-1 inhibits the transfer of lipids between high-density lipoproteins (HDL) and cells mediated by SR-BI. BLT-1 has pro-inflammatory functions through neutrophil recruitment[1][2][3].

In Vitro

BLT-1 has IC50s of 60 and 110 nM for cellular DiI-HDL and [3H]CE-HDL uptake in ldlA[mSR-BI] cells[1].
BLT-1 (50 μM; 3 hours) does not induce general defects in clathrin-dependent and -independent intracellular membrane trafficking in HeLa, BSC-1 cells[1].
BLT-1 can inhibit SR-BI-dependent selective uptake of [3H]CE from [3H]CE-HDL by mSR-BI-t1-containing liposomes in cells (IC50=0.057 µM) and liposomes (IC50=0.098 µM) [2].

Molecular Weight

241.40

Formula

C₁₂H₂₃N₃S

CAS No.

321673-30-7

SMILES

CCCCCCC1CCC/C1=N/NC(N)=S

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

BLT-1BLT1BLT 1OthersTransferlipidshigh-densitylipoproteinsHDLscavengerSR-BIpro-inflammatoryneutrophilrecruitmentthiosemicarbazonecopperchelatorInhibitorinhibitorinhibit

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