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  2. HCV
  3. BLT-1

BLT-1 

Cat. No.: HY-116767 Purity: 98.83%
Handling Instructions

BLT-1, a thiosemicarbazone copper chelator, is a selective scavenger receptor B, type 1 (SR-BI) inhibitor. BLT-1 inhibits the transfer of lipids between high-density lipoproteins (HDL) and cells mediated by SR-BI. BLT-1 is a potent HCV entry inhibitor. BLT-1 has pro-inflammatory functions through neutrophil recruitment.

For research use only. We do not sell to patients.

BLT-1 Chemical Structure

BLT-1 Chemical Structure

CAS No. : 321673-30-7

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5 mg USD 110 In-stock
Estimated Time of Arrival: December 31
10 mg USD 200 In-stock
Estimated Time of Arrival: December 31
50 mg USD 550 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

BLT-1, a thiosemicarbazone copper chelator, is a selective scavenger receptor B, type 1 (SR-BI) inhibitor. BLT-1 inhibits the transfer of lipids between high-density lipoproteins (HDL) and cells mediated by SR-BI. BLT-1 is a potent HCV entry inhibitor. BLT-1 has pro-inflammatory functions through neutrophil recruitment[1][2][3][4].

In Vitro

BLT-1 has IC50s of 60 and 110 nM for cellular DiI-HDL and [3H]CE-HDL uptake in ldlA[mSR-BI] cells[1].
BLT-1 has an IC50 of 0.96 μM for the HCV entry in Huh 7.5.1 cells[4].
BLT-1 (50 μM; 3 hours) does not induce general defects in clathrin-dependent and -independent intracellular membrane trafficking in HeLa, BSC-1 cells[1].
BLT-1 can inhibit SR-BI-dependent selective uptake of [3H]CE from [3H]CE-HDL by mSR-BI-t1-containing liposomes in cells (IC50=0.057 µM) and liposomes (IC50=0.098 µM) [2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

241.40

Formula

C₁₂H₂₃N₃S

CAS No.

321673-30-7

SMILES

CCCCCCC1CCC/C1=N/NC(N)=S

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 41.67 mg/mL (172.62 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.1425 mL 20.7125 mL 41.4250 mL
5 mM 0.8285 mL 4.1425 mL 8.2850 mL
10 mM 0.4143 mL 2.0713 mL 4.1425 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (8.62 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.08 mg/mL (8.62 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (8.62 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 98.83%

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  • Molarity Calculator

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The molarity calculator equation

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
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Keywords:

BLT-1BLT1BLT 1HCVHepatitis C virusTransferlipidshigh-densitylipoproteinsHDLscavengerSR-BIpro-inflammatoryneutrophilrecruitmentthiosemicarbazonecopperchelatorInhibitorinhibitorinhibit

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Product Name:
BLT-1
Cat. No.:
HY-116767
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