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Cat. No.: HY-P4810

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Polyphemusin II-Derived Peptide

(Synonyms: T140)

Polyphemusin II-Derived Peptide (T140), a CXCR4 inhibitor, shows high inhibitory activity against HIV-1 entry and the inhibitory effect on the binding of an anti-CXCR4 monoclonal antibody (12G5) to CXCR4.

For research use only. We do not sell to patients.

CAS No.: 229030-20-0
Formula: C₉₀H₁₄₁N₃₃O₁₈S₂
Molecular Weight:2037.42

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Polyphemusin II-Derived Peptide Chemical Structure

CAS No.: 229030-20-0

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All CXCR Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
MT4	CC₅₀	>>1 μM Compound: T140	Compound was tested for reduction of the viability of mock infected MT-4 cell in test-I Compound was tested for reduction of the viability of mock infected MT-4 cell in test-I	[PMID: 11128640]
MT4	CC₅₀	96 μM Compound: T140	Compound was tested for reduction of the viability of mock infected MT-4 cell in test-II Compound was tested for reduction of the viability of mock infected MT-4 cell in test-II	[PMID: 11128640]
MT4	EC₅₀	3.3 nM Compound: T140	Inhibition of HIV-induced cytopathogenicity in MT-4 cell Inhibition of HIV-induced cytopathogenicity in MT-4 cell	[PMID: 11128640]

Chemical Information

CAS No. 229030-20-0
Molecular Weight 2037.42
Formula C₉₀H₁₄₁N₃₃O₁₈S₂
Synonyms

T140
Sequence

Arg-Arg-{2Nal}-Cys-Tyr-Arg-Lys-{dLys}-Pro-Tyr-Arg-{Cit}-Cys-Arg (Disulfide bridge:Cys4-Cys13)
Sequence Shortening

RR-{2Nal}-CYRK-{dLys}-PYR-{Cit}-CR (Disulfide bridge:Cys4-Cys13)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (258 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. H Tamamura, et al. A low-molecular-weight inhibitor against the chemokine receptor CXCR4: a strong anti-HIV peptide T140. Biochem Biophys Res Commun. 1998 Dec 30;253(3):877-82. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
Chemical Information
Purity & Documentation
References

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Polyphemusin II-Derived Peptide

All CXCR Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Polyphemusin II-Derived Peptide Related Classifications

HY-P4810 Related Classifications