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Cat. No.: HY-P4810

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Polyphemusin II-Derived Peptide

(Synonyms: T140)

Polyphemusin II-Derived Peptide (T140), a CXCR4 inhibitor, shows high inhibitory activity against HIV-1 entry and the inhibitory effect on the binding of an anti-CXCR4 monoclonal antibody (12G5) to CXCR4.

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CAS No.: 229030-20-0
Formule: C₉₀H₁₄₁N₃₃O₁₈S₂
Masse moléculaire:2037.42

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Please store the product under the recommended conditions in the Certificate of Analysis.

Polyphemusin II-Derived Peptide Chemical Structure

CAS No.: 229030-20-0

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Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

Voir tous les produits spécifiques à Isoform CXCR :

Cellular Effect

Cell Line	Type	Value	Description	References
MT4	CC₅₀	>>1 μM Compound: T140	Compound was tested for reduction of the viability of mock infected MT-4 cell in test-I Compound was tested for reduction of the viability of mock infected MT-4 cell in test-I	[PMID: 11128640]
MT4	CC₅₀	96 μM Compound: T140	Compound was tested for reduction of the viability of mock infected MT-4 cell in test-II Compound was tested for reduction of the viability of mock infected MT-4 cell in test-II	[PMID: 11128640]
MT4	EC₅₀	3.3 nM Compound: T140	Inhibition of HIV-induced cytopathogenicity in MT-4 cell Inhibition of HIV-induced cytopathogenicity in MT-4 cell	[PMID: 11128640]

Chemical Information

CAS No. 229030-20-0
Masse moléculaire 2037.42
Formule C₉₀H₁₄₁N₃₃O₁₈S₂
Synonyms

T140
Sequence

Arg-Arg-{2Nal}-Cys-Tyr-Arg-Lys-{dLys}-Pro-Tyr-Arg-{Cit}-Cys-Arg (Disulfide bridge:Cys4-Cys13)
Sequence Shortening

RR-{2Nal}-CYRK-{dLys}-PYR-{Cit}-CR (Disulfide bridge:Cys4-Cys13)
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (258 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. H Tamamura, et al. A low-molecular-weight inhibitor against the chemokine receptor CXCR4: a strong anti-HIV peptide T140. Biochem Biophys Res Commun. 1998 Dec 30;253(3):877-82. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Polyphemusin II-Derived Peptide

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Activité biologique
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Chemical Information
Pureté et documentation
Références

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Polyphemusin II-Derived Peptide

Voir tous les produits spécifiques à Isoform CXCR

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

Polyphemusin II-Derived Peptide Related Classifications

HY-P4810 Related Classifications