BAPTA tetrasodium

Name: BAPTA tetrasodium
Brand: MedChemExpress
SKU: HY-100168A
Rating: 5.0 (36 reviews)

Cat. No.: HY-100168A Purity: 99.70%: Data Sheet
COA

SDS
Handling Instructions
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BAPTA tetrasodium is a selective and cell-impermeant chelator for calcium. BAPTA tetrasodium has high selectivity against magnesium and calcium. BAPTA can also inhibit phospholipase C activity independently of their role as Ca²⁺ chelators.

For research use only. We do not sell to patients.

CAS No. : 126824-24-6

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Customer Review

Based on 36 publication(s) in Google Scholar

Other Forms of BAPTA tetrasodium:

36 Publications Citing Use of MCE BAPTA tetrasodium

RT-PCR

ELISA

: BAPTA tetrasodium purchased from MedChemExpress. Usage Cited in: J Neuroinflammation. 2025 Aug 28;22(1):208. [Abstract]; BAPTA (10 μM). WB results showed that BAPTA could attenuate the Hb-induced decrease in LAMP1 and m-CTSD/pro-CTSD.

: BAPTA tetrasodium purchased from MedChemExpress. Usage Cited in: J Neuroinflammation. 2025 Aug 28;22(1):208. [Abstract]; IF results showed that BAPTA (10 μM) can partially increase the co-localization coefficients of LAMP1 and CTSD.

: BAPTA tetrasodium purchased from MedChemExpress. Usage Cited in: Mil Med Res. 2023 Nov 25;10(1):56. [Abstract]; BAPTA (10 μmol/L, 24 h). qRT-PCR was used to assess the mRNA level of Il6, Tnfα and Tgfβ3 in HMs.

: BAPTA tetrasodium purchased from MedChemExpress. Usage Cited in: Mil Med Res. 2023 Nov 25;10(1):56. [Abstract]; BAPTA (10 μmol/L, 24 h). TGF-β1 and IL-6 level in the supernatant of HMs were detected by ELISA.

: BAPTA tetrasodium purchased from MedChemExpress. Usage Cited in: Mil Med Res. 2023 Nov 25;10(1):56. [Abstract]; BAPTA (10 μmol/L, 24 h). The expression and location of TNF-α in HMs was assessed by confocal microscopy (c). Scale bar = 20 μm.

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

BAPTA tetrasodium is widely used as an intracellular buffer to investigate the effects caused by Ca²⁺ release from intracellular calcium stores or Ca²⁺ influx via Ca²⁺-permeable channels in the plasma membrane^[1].
BAPTA tetrasodium can be introduced into cells via methods such as patch-clamp and microinjection^[1].
BAPTA tetrasodium inhibits PLC activity in isolated Drosophila melanogaster photoreceptor cells with an IC₅₀ of approximately 8 mM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

564.36

Formula

C₂₂H₂₀N₂Na₄O₁₀

CAS No.

126824-24-6

Appearance

Solid

Color

White to off-white

SMILES

O=C(O[Na])CN(C1=CC=CC=C1OCCOC2=CC=CC=C2N(CC(O[Na])=O)CC(O[Na])=O)CC(O[Na])=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (177.19 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.7719 mL	8.8596 mL	17.7192 mL
5 mM	0.3544 mL	1.7719 mL	3.5438 mL
10 mM	0.1772 mL	0.8860 mL	1.7719 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.70%

Select Batch:

Data Sheet (275 KB) SDS (393 KB)

COA (251 KB) HNMR (283 KB) LCMS (94 KB)

Handling Instructions (2659 KB)

References

[1]. R Y Tsien, et al. New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures. Biochemistry. 1980 May 27;19(11):2396-404. [Content Brief]

[2]. Roger C Hardie, et al. Inhibition of phospholipase C activity in Drosophila photoreceptors by 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid (BAPTA) and di-bromo BAPTA. Cell Calcium. 2005 Dec;38(6):547-56. [Content Brief]

[3]. M B Collatz, et al. Intracellular calcium chelator BAPTA protects cells against toxic calcium overload but also alters physiological calcium responses. Cell Calcium [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	1.7719 mL	8.8596 mL	17.7192 mL	44.2980 mL
	5 mM	0.3544 mL	1.7719 mL	3.5438 mL	8.8596 mL
	10 mM	0.1772 mL	0.8860 mL	1.7719 mL	4.4298 mL
	15 mM	0.1181 mL	0.5906 mL	1.1813 mL	2.9532 mL
	20 mM	0.0886 mL	0.4430 mL	0.8860 mL	2.2149 mL
	25 mM	0.0709 mL	0.3544 mL	0.7088 mL	1.7719 mL
	30 mM	0.0591 mL	0.2953 mL	0.5906 mL	1.4766 mL
	40 mM	0.0443 mL	0.2215 mL	0.4430 mL	1.1074 mL
	50 mM	0.0354 mL	0.1772 mL	0.3544 mL	0.8860 mL
	60 mM	0.0295 mL	0.1477 mL	0.2953 mL	0.7383 mL
	80 mM	0.0221 mL	0.1107 mL	0.2215 mL	0.5537 mL
	100 mM	0.0177 mL	0.0886 mL	0.1772 mL	0.4430 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.