BAPTA tetrapotassium
Based on 37 publication(s) in Google Scholar
BAPTA tetrapotassium is a selective and cell-impermeant chelator for calcium. BAPTA has high selectivity against magnesium and calcium. BAPTA tetrapotassium can also inhibit phospholipase C activity independently of their role as Ca2+ chelators.
For research use only. We do not sell to patients.
- Purity: 99.42%
- CAS No.: 73630-08-7
- Formula: C22H20K4N2O10
- Molecular Weight:628.79
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) BAPTA tetrapotassium
More- Mil Med Res. 2023 Nov 25;10(1):56. [Abstract]
- Sci Immunol. 2019 Jun 28;4(36):eaau6426. [Abstract]
- Adv Sci (Weinh). 2021 Aug;8(15):e2100363. [Abstract]
- J Clin Invest. 2024 Apr 25;134(12):e176355. [Abstract]
- J Neuroinflammation. 2025 Aug 28;22(1):208. [Abstract]
- Environ Chem Ecotoxicol. 2025 Nov 19;8:267-280.
- Free Radic Biol Med. 2024 Mar:213:150-163. [Abstract]
- Sci Total Environ. 2020 Feb 10;703:134702. [Abstract]
- Biomed Pharmacother. 2023 Oct:166:115343. [Abstract]
- Biomed Pharmacother. 2023 May:161:114480. [Abstract]
- Cell Death Discov. 2026 May 25. [Abstract]
- Cell Rep. 2025 Dec 10;44(12):116673. [Abstract]
- J Pineal Res. 2024 Aug;76(5):e12987. [Abstract]
- J Invest Dermatol. 2024 May 30:S0022-202X(24)00384-1. [Abstract]
- J Ginseng Res. 2022 Jul;46(4):515-525. [Abstract]
- J Ethnopharmacol. 2025 Apr 29:348:119863. [Abstract]
- J Ethnopharmacol. 2023 Feb 10;302(Pt A):115923. [Abstract]
- Int J Pharm. 2025 Nov 10:684:126125. [Abstract]
- J Thromb Haemost. 2021 Dec;19(12):3113-3125. [Abstract]
- Int J Mol Sci. 2026 Jan 1;27(1):468. [Abstract]
- Int Immunopharmacol. 2026 Mar 1:172:116168. [Abstract]
- Toxicology. 2023 Dec:500:153674. [Abstract]
- Biochim Biophys Acta Mol Basis Dis. 2025 Jul 18;1871(8):167990. [Abstract]
- Exp Neurol. 2023 May:363:114350. [Abstract]
- J Cell Mol Med. 2020 Aug;24(16):9287-9299. [Abstract]
- J Funct Foods. 2024 Oct.
- J Funct Foods. December 2021, 104791.
- Aging. 2019 Nov 22;11(22):10385-10408. [Abstract]
- Cell Signal. 2025 Jul:131:111753. [Abstract]
- Mol Med Rep. 2024 Jan;29(1):13. [Abstract]
- Cardiovasc Ther. 2023 Mar 30:2023:3939360. [Abstract]
- J Pharm Pharmacol. 2024 May 3;76(5):567-578. [Abstract]
- J Cancer. 2024 Jan 1;15(2):343-355. [Abstract]
- Vet Microbiol. 2019 Dec;239:108498. [Abstract]
- Toxicon. 2026 Jun 15:276:109072. [Abstract]
- Res Sq. 2025 Apr 18.
- bioRxiv. 2023 Jun 25.
Customer Validation & Images
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WB
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IF
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RT-PCR
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ELISA
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IF
All Phospholipase Isoforms
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Biological Activity
BAPTA tetrapotassium is widely used as an intracellular buffer to investigate the effects caused by Ca2+ release from intracellular calcium stores or Ca2+ influx via Ca2+-permeable channels in the plasma membrane[1].
BAPTA tetrapotassium can be introduced into cells via methods such as patch-clamp and microinjection[1].
BAPTA tetrapotassium inhibits PLC activity in isolated Drosophila melanogaster photoreceptor cells with an IC50 of approximately 8 mM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 73630-08-7
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Appearance Solid
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Molecular Weight 628.79
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Formula C22H20K4N2O10
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Color White to off-white
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SMILES
O=C(O[K])CN(C1=CC=CC=C1OCCOC2=CC=CC=C2N(CC(O[K])=O)CC(O[K])=O)CC(O[K])=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (37)
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Journal Impact Factor
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Most Recent
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Mil Med Res
Targeting GPR65 alleviates hepatic inflammation and fibrosis by suppressing the JNK and NF-κB pathways. [Abstract]2023 Nov 25;10(1):56. PMID: 38001521
BAPTA tetrapotassium purchased from MedChemExpress. Usage Cited in: Mil Med Res. 2023 Nov 25;10(1):56. [Abstract]
BAPTA (10 μmol/L, 24 h). qRT-PCR was used to assess the mRNA level of Il6, Tnfα and Tgfβ3 in HMs.
BAPTA tetrapotassium purchased from MedChemExpress. Usage Cited in: Mil Med Res. 2023 Nov 25;10(1):56. [Abstract]
BAPTA (10 μmol/L, 24 h). TGF-β1 and IL-6 level in the supernatant of HMs were detected by ELISA.
BAPTA tetrapotassium purchased from MedChemExpress. Usage Cited in: Mil Med Res. 2023 Nov 25;10(1):56. [Abstract]
BAPTA (10 μmol/L, 24 h). The expression and location of TNF-α in HMs was assessed by confocal microscopy (c). Scale bar = 20 μm.
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Sci Immunol
2019 Jun 28;4(36):eaau6426. PMID: 31253642 -
Adv Sci (Weinh)
2021 Aug;8(15):e2100363. PMID: 34047068 -
J Clin Invest
Chromosomal 3q amplicon encodes essential regulators of secretory vesicles that drive secretory addiction in cancer. [Abstract]2024 Apr 25;134(12):e176355. PMID: 38662435 -
J Neuroinflammation
P2X7-CaMKII drives 5-LOX nuclear translocation to impair microglial function after subarachnoid hemorrhage. [Abstract]2025 Aug 28;22(1):208. PMID: 40877894
BAPTA tetrapotassium purchased from MedChemExpress. Usage Cited in: J Neuroinflammation. 2025 Aug 28;22(1):208. [Abstract]
BAPTA (10 μM). WB results showed that BAPTA could attenuate the Hb-induced decrease in LAMP1 and m-CTSD/pro-CTSD.
BAPTA tetrapotassium purchased from MedChemExpress. Usage Cited in: J Neuroinflammation. 2025 Aug 28;22(1):208. [Abstract]
IF results showed that BAPTA (10 μM) can partially increase the co-localization coefficients of LAMP1 and CTSD.
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Free Radic Biol Med
Quercetin induces ferroptosis in gastric cancer cells by targeting SLC1A5 and regulating the p-Camk2/p-DRP1 and NRF2/GPX4 Axes. [Abstract]2024 Mar:213:150-163. PMID: 38190923 -
Sci Total Environ
Microcystin-leucine-arginine induced neurotoxicity by initiating mitochondrial fission in hippocampal neurons. [Abstract]2020 Feb 10;703:134702. PMID: 31753492 -
Biomed Pharmacother
Barasertib impedes chondrocyte senescence and alleviates osteoarthritis by mitigating the destabilization of heterochromatin induced by AURKB. [Abstract]2023 Oct:166:115343. PMID: 37634474 -
Biomed Pharmacother
Interruption of TRPC6-NFATC1 signaling inhibits NADPH oxidase 4 and VSMCs phenotypic switch in intracranial aneurysm. [Abstract]2023 May:161:114480. PMID: 37002575 -
Cell Death Discov
ATP2B4 driven chromatin compaction exacerbates pancreatic cancer radiotherapy resistance. [Abstract]2026 May 25. PMID: 42185253 -
Cell Rep
Aryl hydrocarbon receptor-induced activation of AIM2 inflammasome is mediated by MOMP and MPT: A vital therapeutic pathway for inflammation. [Abstract]2025 Dec 10;44(12):116673. PMID: 41385364 -
J Pineal Res
2024 Aug;76(5):e12987. PMID: 38975671 -
J Invest Dermatol
TRPV3-Activated PARP1/AIFM1/MIF Axis through Oxidative Stress Contributes to Atopic Dermatitis. [Abstract]2024 May 30:S0022-202X(24)00384-1. PMID: 38823435 -
J Ginseng Res
Ginsenoside Rg1 attenuates cerebral ischemia-reperfusion injury due to inhibition of NOX2-mediated calcium homeostasis dysregulation in mice. [Abstract]2022 Jul;46(4):515-525. PMID: 35818419 -
J Ethnopharmacol
Ginsenoside Rg1 attenuates T2DM-induced renal damage and fibrosis by inhibiting TRPC6-ChREBP-TXNIP signaling. [Abstract]2025 Apr 29:348:119863. PMID: 40311716 -
J Ethnopharmacol
Ginsenoside Rg1 attenuates glomerular fibrosis by inhibiting CD36/TRPC6/NFAT2 signaling in type 2 diabetes mellitus mice. [Abstract]2023 Feb 10;302(Pt A):115923. PMID: 36375645 -
Int J Pharm
Reversible increased basement membrane permeability and calcium ion redistribution facilitate ultrasound-enhanced transdermal drug delivery efficiency. [Abstract]2025 Nov 10:684:126125. PMID: 40914558 -
J Thromb Haemost
2021 Dec;19(12):3113-3125. PMID: 34411418 -
Int J Mol Sci
Gut Microbiota-Derived Propionic Acid Mediates ApoA-I-Induced Amelioration of MASLD via Activation of GPR43-Ca2+-CAMKII-ATGL Hepatic Lipolysis. [Abstract]2026 Jan 1;27(1):468. PMID: 41516340 -
Int Immunopharmacol
Piezo1 activates Wnt5a/FZD4 signaling to promote osteogenesis and mitigates age-associated bone loss. [Abstract]2026 Mar 1:172:116168. PMID: 41529412 -
Toxicology
Nonivamide inhibits proliferation of human corneal epithelial cells by inducing cell cycle arrest and oxidative stress. [Abstract]2023 Dec:500:153674. PMID: 37989449 -
Biochim Biophys Acta Mol Basis Dis
Activation of IRF2 signaling networks facilitates podocyte pyroptosis in lupus nephritis. [Abstract]2025 Jul 18;1871(8):167990. PMID: 40684959 -
Exp Neurol
Trpc6 knockout improves behavioral dysfunction and reduces Aβ production by inhibiting CN-NFAT1 signaling in T2DM mice. [Abstract]2023 May:363:114350. PMID: 36791875 -
J Cell Mol Med
Calpain-2 plays a pivotal role in the inhibitory effects of propofol against TNF-α-induced autophagy in mouse hippocampal neurons. [Abstract]2020 Aug;24(16):9287-9299. PMID: 32627970 -
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Aging
Rotating magnetic field delays human umbilical vein endothelial cell aging and prolongs the lifespan of Caenorhabditis elegans. [Abstract]2019 Nov 22;11(22):10385-10408. PMID: 31757933 -
Cell Signal
Rosuvastatin inhibits carcinogenesis through Ca2+ triggered endoplasmic reticulum stress pathway in pancreatic cancer. [Abstract]2025 Jul:131:111753. PMID: 40107481 -
Mol Med Rep
Trpc6 knockout protects against renal fibrosis by restraining the CN‑NFAT2 signaling pathway in T2DM mice. [Abstract]2024 Jan;29(1):13. PMID: 38038121 -
Cardiovasc Ther
KCa3.1 Promotes Proinflammatory Exosome Secretion by Activating AKT/Rab27a in Atrial Myocytes during Rapid Pacing. [Abstract]2023 Mar 30:2023:3939360. PMID: 37035755 -
J Pharm Pharmacol
2024 May 3;76(5):567-578. PMID: 38271051 -
J Cancer
JS-K activates G2/M checkpoints through the DNA damage response and induces autophagy via CAMKKβ/AMPKα/mTOR pathway in bladder cancer cells. [Abstract]2024 Jan 1;15(2):343-355. PMID: 38169515 -
Vet Microbiol
S100A9 regulates porcine reproductive and respiratory syndrome virus replication by interacting with the viral nucleocapsid protein. [Abstract]2019 Dec;239:108498. PMID: 31767072 -
Toxicon
Transient receptor potential canonical 6 is critical for chronic lipopolysaccharide exposure-induced pulmonary injury and fibrosis. [Abstract]2026 Jun 15:276:109072. PMID: 41850440 -
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Solvent & Solubility
H2O : 100 mg/mL (159.04 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. R Y Tsien, et al. New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures. Biochemistry. 1980 May 27;19(11):2396-404. [Content Brief]
[2]. Roger C Hardie, et al. Inhibition of phospholipase C activity in Drosophila photoreceptors by 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid (BAPTA) and di-bromo BAPTA. Cell Calcium. 2005 Dec;38(6):547-56. [Content Brief]
[3]. M B Collatz, et al. Intracellular calcium chelator BAPTA protects cells against toxic calcium overload but also alters physiological calcium responses. Cell Calcium [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.5904 mL | 7.9518 mL | 15.9036 mL | 39.7589 mL |
| 5 mM | 0.3181 mL | 1.5904 mL | 3.1807 mL | 7.9518 mL | |
| 10 mM | 0.1590 mL | 0.7952 mL | 1.5904 mL | 3.9759 mL | |
| 15 mM | 0.1060 mL | 0.5301 mL | 1.0602 mL | 2.6506 mL | |
| 20 mM | 0.0795 mL | 0.3976 mL | 0.7952 mL | 1.9879 mL | |
| 25 mM | 0.0636 mL | 0.3181 mL | 0.6361 mL | 1.5904 mL | |
| 30 mM | 0.0530 mL | 0.2651 mL | 0.5301 mL | 1.3253 mL | |
| 40 mM | 0.0398 mL | 0.1988 mL | 0.3976 mL | 0.9940 mL | |
| 50 mM | 0.0318 mL | 0.1590 mL | 0.3181 mL | 0.7952 mL | |
| 60 mM | 0.0265 mL | 0.1325 mL | 0.2651 mL | 0.6626 mL | |
| 80 mM | 0.0199 mL | 0.0994 mL | 0.1988 mL | 0.4970 mL | |
| 100 mM | 0.0159 mL | 0.0795 mL | 0.1590 mL | 0.3976 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
BAPTA tetrapotassium Related Classifications
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