BAPTA tetrapotassium

Name: BAPTA tetrapotassium
Brand: MedChemExpress
SKU: HY-100168B
Rating: 5.0 (36 reviews)

Cat. No.: HY-100168B Purity: 99.45%: Data Sheet
COA

SDS
Handling Instructions
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BAPTA tetrapotassium is a selective and cell-impermeant chelator for calcium. BAPTA has high selectivity against magnesium and calcium. BAPTA tetrapotassium can also inhibit phospholipase C activity independently of their role as Ca²⁺ chelators.

For research use only. We do not sell to patients.

CAS No. : 73630-08-7

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	In-stock	Estimated Time of Arrival: December 31
Solid
100 mg	In-stock	Estimated Time of Arrival: December 31
250 mg	In-stock	Estimated Time of Arrival: December 31
500 mg	Get quote
1 g	Get quote

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Customer Review

Based on 36 publication(s) in Google Scholar

Other Forms of BAPTA tetrapotassium:

BAPTA In-stock
BAPTA tetrasodium In-stock
BAPTA tetrapotassium (Standard) Get quote

36 Publications Citing Use of MCE BAPTA tetrapotassium

RT-PCR

ELISA

: BAPTA tetrapotassium purchased from MedChemExpress. Usage Cited in: J Neuroinflammation. 2025 Aug 28;22(1):208. [Abstract]; BAPTA (10 μM). WB results showed that BAPTA could attenuate the Hb-induced decrease in LAMP1 and m-CTSD/pro-CTSD.

: BAPTA tetrapotassium purchased from MedChemExpress. Usage Cited in: J Neuroinflammation. 2025 Aug 28;22(1):208. [Abstract]; IF results showed that BAPTA (10 μM) can partially increase the co-localization coefficients of LAMP1 and CTSD.

: BAPTA tetrapotassium purchased from MedChemExpress. Usage Cited in: Mil Med Res. 2023 Nov 25;10(1):56. [Abstract]; BAPTA (10 μmol/L, 24 h). qRT-PCR was used to assess the mRNA level of Il6, Tnfα and Tgfβ3 in HMs.

: BAPTA tetrapotassium purchased from MedChemExpress. Usage Cited in: Mil Med Res. 2023 Nov 25;10(1):56. [Abstract]; BAPTA (10 μmol/L, 24 h). TGF-β1 and IL-6 level in the supernatant of HMs were detected by ELISA.

: BAPTA tetrapotassium purchased from MedChemExpress. Usage Cited in: Mil Med Res. 2023 Nov 25;10(1):56. [Abstract]; BAPTA (10 μmol/L, 24 h). The expression and location of TNF-α in HMs was assessed by confocal microscopy (c). Scale bar = 20 μm.

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

BAPTA tetrapotassium is widely used as an intracellular buffer to investigate the effects caused by Ca²⁺ release from intracellular calcium stores or Ca²⁺ influx via Ca²⁺-permeable channels in the plasma membrane^[1].
BAPTA tetrapotassium can be introduced into cells via methods such as patch-clamp and microinjection^[1].
BAPTA tetrapotassium inhibits PLC activity in isolated Drosophila melanogaster photoreceptor cells with an IC₅₀ of approximately 8 mM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

628.79

Formula

C₂₂H₂₀K₄N₂O₁₀

CAS No.

73630-08-7

Appearance

Solid

Color

White to off-white

SMILES

O=C(O[K])CN(C1=CC=CC=C1OCCOC2=CC=CC=C2N(CC(O[K])=O)CC(O[K])=O)CC(O[K])=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (159.04 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.5904 mL	7.9518 mL	15.9036 mL
5 mM	0.3181 mL	1.5904 mL	3.1807 mL
10 mM	0.1590 mL	0.7952 mL	1.5904 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.45%

Select Batch:

Data Sheet (275 KB) SDS (394 KB)

COA (251 KB) HNMR (275 KB) LCMS (94 KB)

Handling Instructions (2659 KB)

References

[1]. R Y Tsien, et al. New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures. Biochemistry. 1980 May 27;19(11):2396-404. [Content Brief]

[2]. Roger C Hardie, et al. Inhibition of phospholipase C activity in Drosophila photoreceptors by 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid (BAPTA) and di-bromo BAPTA. Cell Calcium. 2005 Dec;38(6):547-56. [Content Brief]

[3]. M B Collatz, et al. Intracellular calcium chelator BAPTA protects cells against toxic calcium overload but also alters physiological calcium responses. Cell Calcium [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	1.5904 mL	7.9518 mL	15.9036 mL	39.7589 mL
	5 mM	0.3181 mL	1.5904 mL	3.1807 mL	7.9518 mL
	10 mM	0.1590 mL	0.7952 mL	1.5904 mL	3.9759 mL
	15 mM	0.1060 mL	0.5301 mL	1.0602 mL	2.6506 mL
	20 mM	0.0795 mL	0.3976 mL	0.7952 mL	1.9879 mL
	25 mM	0.0636 mL	0.3181 mL	0.6361 mL	1.5904 mL
	30 mM	0.0530 mL	0.2651 mL	0.5301 mL	1.3253 mL
	40 mM	0.0398 mL	0.1988 mL	0.3976 mL	0.9940 mL
	50 mM	0.0318 mL	0.1590 mL	0.3181 mL	0.7952 mL
	60 mM	0.0265 mL	0.1325 mL	0.2651 mL	0.6626 mL
	80 mM	0.0199 mL	0.0994 mL	0.1988 mL	0.4970 mL
	100 mM	0.0159 mL	0.0795 mL	0.1590 mL	0.3976 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.