1. Antibody-drug Conjugate/ADC Related
  2. ADC Linker
  3. Maleimide-DOTA

Maleimide-DOTA (Synonyms: Maleimido-mono-amide-DOTA)

Cat. No.: HY-133540 Purity: 98.01%
Handling Instructions

Maleimide-DOTA is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

Maleimide-DOTA Chemical Structure

Maleimide-DOTA Chemical Structure

CAS No. : 1006711-90-5

Size Price Stock Quantity
50 mg USD 380 In-stock
Estimated Time of Arrival: December 31
100 mg USD 650 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Maleimide-DOTA is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

IC50 & Target

Non-cleavable

 

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

526.54

Formula

C₂₂H₃₄N₆O₉

CAS No.

1006711-90-5

SMILES

O=C(O)CN1CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(NCCN2C(C=CC2=O)=O)=O)CC1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (237.40 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8992 mL 9.4960 mL 18.9919 mL
5 mM 0.3798 mL 1.8992 mL 3.7984 mL
10 mM 0.1899 mL 0.9496 mL 1.8992 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (3.95 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (3.95 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (3.95 mM); Clear solution

*All of the co-solvents are provided by MCE.
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  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Maleimide-DOTAMaleimido-mono-amide-DOTAADC LinkerAntibody-drug conjugates linkerInhibitorinhibitorinhibit

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Product Name:
Maleimide-DOTA
Cat. No.:
HY-133540
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