1295584-83-6
Chemical Structure
Maleimide-NOTA
- CAS No.: 1295584-83-6
- Formula:C18H27N5O7
- Molecular Weight:425.44
IUPAC Name: 2,2'-(7-(2-((2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethyl)amino)-2-oxoethyl)-1,4,7-triazonane-1,4-diyl)diacetic acid
InChIKey: JZFBXLDURQNNQU-UHFFFAOYSA-N
SMILES: O=C(O)CN1CCN(CC(NCCN2C(C=CC2=O)=O)=O)CCN(CC(O)=O)CC1
Biological Activity: Maleimide-NOTA is a chelate. Maleimide-NOTA can be site-specifically coupled to the hPD-L1 nanobody bearing the Cys-tag. Maleimide-NOTA can specifically conjugate to A20FMDV2 (HY-P1654). The [68Ga]Ac-CG6 formed by the conjugation of 68Ga radiolabeled Maleimide-NOTA with A20FMDV2 can be used for PET imaging of αvβ6 integrin-positive pancreatic ductal adenocarcinoma[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Maleimide-NOTA | 99.26% | Maleimide-NOTA is a chelate. Maleimide-NOTA can be site-specifically coupled to the hPD-L1 nanobody bearing the Cys-tag. Maleimide-NOTA can specifically conjugate to A20FMDV2 (HY-P1654). The [68Ga]Ac-CG6 formed by the conjugation of 68Ga radiolabeled Maleimide-NOTA with A20FMDV2 can be used for PET imaging of αvβ6 integrin-positive pancreatic ductal adenocarcinoma. | ||||||||||||||||||||
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- [1]. Ui T, et al. Development and characterization of a 68Ga-labeled A20FMDV2 peptide probe for the PET imaging of αvβ6 integrin-positive pancreatic ductal adenocarcinoma. Bioorg Med Chem. 2020 Jan 1;28(1):115189. [Content Brief]
- [2]. Chigoho DM, et al. Site-Specific Radiolabeling of a Human PD-L1 Nanobody via Maleimide-Cysteine Chemistry. Pharmaceuticals (Basel). 2021;14(6):550. Published 2021 Jun 8. [Content Brief]
Keywords
