16858-02-9
16858-02-9
Chemical Structure
TPEN
Synonym(s): TPEDA
- CAS No.: 16858-02-9
- Formula:C26H28N6
- Molecular Weight:424.55
IUPAC Name: N1,N1,N2,N2-tetrakis(pyridin-2-ylmethyl)ethane-1,2-diamine
InChIKey: CVRXLMUYFMERMJ-UHFFFAOYSA-N
SMILES: N(CC1=NC=CC=C1)(CC2=NC=CC=C2)CCN(CC3=NC=CC=C3)CC4=NC=CC=C4
Biological Activity: TPEN (TPEDA) is a specific cell-permeable heavy metal chelator. TPEN has a higher affinity for Zn2+, but a lower affinity for Mg2+ and Ca2+. TPEN induces DNA damage and increases intracellular ROS production. TPEN also inhibits cell proliferation and induces apoptosis[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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TPEN | 99.91% | TPEN (TPEDA) is a specific cell-permeable heavy metal chelator. TPEN has a higher affinity for Zn2+, but a lower affinity for Mg2+ and Ca2+. TPEN induces DNA damage and increases intracellular ROS production. TPEN also inhibits cell proliferation and induces apoptosis. | ||||||||||||||||||||
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TPEN (Standard) | ≥98% | TPEN (Standard) is the analytical standard of TPEN (HY-100202). This product is intended for research and analytical applications. TPEN (TPEDA) is a specific cell-permeable heavy metal chelator. TPEN has a higher affinity for Zn2+, but a lower affinity for Mg2+ and Ca2+. TPEN induces DNA damage and increases intracellular ROS production. TPEN also inhibits cell proliferation and induces apoptosis. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.93
HY-W075525N1,N1,N3,N3-Tetrakis(pyridin-2-ylmethyl)propane-1,3-diamine -
Similarity Score 0.81
HY-W075532N1-Benzyl-N1,N3,N3-tris(pyridin-2-ylmethyl)propane-1,3-diamine -
Similarity Score 0.80
HY-W456298N,N'-(Pyridine-2,6-diylbis(methylene))bis(1-(pyridin-2-yl)-N-(pyridin-2-ylmethyl)methanamine) -
Similarity Score 0.75
HY-W034703Tris(2-pyridylmethyl)amine -
Similarity Score 0.74
HY-W4890852,6-Bis((bis(pyridin-2-ylmethyl)amino)methyl)-4-methylphenol -
Similarity Score 0.69
HY-W5608211,1'-(5-(4-Aminobutoxy)-1,3-phenylene)bis(n,n-bis(pyridin-2-ylmethyl)methanamine) -
Similarity Score 0.69
HY-120420N4Py -
Similarity Score 0.65
HY-W075527N1,N1-Bis(pyridin-2-ylmethyl)ethane-1,2-diamine -
Similarity Score 0.61
HY-W075528N,N'-Dimethyl-N,N'-bis(2-pyridylmethyl)ethane-1,2-diamine -
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References
- [1]. Ohkubo M, et al. Heavy metal chelator TPEN attenuates fura-2 fluorescence changes induced by cadmium, mercury and methylmercury. J Vet Med Sci. 2016 Jun 1;78(5):761-7. [Content Brief]
- [2]. Rahal ON, et al. Chk1 and DNA-PK mediate TPEN-induced DNA damage in a ROS dependent manner in human colon cancer cells. Cancer Biol Ther. 2016 Nov;17(11):1139-1148. [Content Brief]
- [3]. E Aizenman, et al. Induction of neuronal apoptosis by thiol oxidation: putative role of intracellular zinc release. J Neurochem. 2000 Nov;75(5):1878-88. [Content Brief]
