2. Anti-infection
  3. Bacterial Antibiotic
  4. 8-Hydroxyquinoline

8-Hydroxyquinoline  (Synonyms: 8-Quinolinol)

Cat. No.: HY-B1005 Purity: 99.99%
COA Handling Instructions

8-Hydroxyquinoline (8-Quinolinol) is a lipophilic metal chelator that can be used as a fungicide .8-Hydroxyquinoline shows the MIC range of 27.56-55.11 μM (4-8 μg/mL) against the clinical isolates of Neisseria gonorrhoeae. 8-Hydroxyquinoline can bind to copper form complexes and transport copper into cells. 8-Hydroxyquinoline increases in the number of micronucleated polychromatic erythrocytes and can also make hair depigmented in mice.

For research use only. We do not sell to patients.

8-Hydroxyquinoline Chemical Structure

8-Hydroxyquinoline Chemical Structure

CAS No. : 148-24-3

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Based on 1 publication(s) in Google Scholar

Other Forms of 8-Hydroxyquinoline:

8-Hydroxyquinoline Related Antibodies

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Description

8-Hydroxyquinoline (8-Quinolinol) is a lipophilic metal chelator that can be used as a fungicide .8-Hydroxyquinoline shows the MIC range of 27.56-55.11 μM (4-8 μg/mL) against the clinical isolates of Neisseria gonorrhoeae. 8-Hydroxyquinoline can bind to copper form complexes and transport copper into cells. 8-Hydroxyquinoline increases in the number of micronucleated polychromatic erythrocytes and can also make hair depigmented in mice[1][2][3][4][5].

In Vitro

8-Hydroxyquinoline (8HQ) (Compd 1) shows cytotoxicity in MRC-5 cells with an IC50 of 6.27 μM[1].
8-Hydroxyquinoline (8-OHQ) (Compd 1) (mixture of CuCl2 at 10.0 μM, 1 hour) binds to copper and form complexes can facilitate transport of copper into human breast cancer DCIS cells[2].
8-Hydroxyquinoline (mixture of CuCl2 at 1-20 μM; 1 or 8 hour) binds to copper and form complexes induces cell death with a time and dose-dependent manner in DCIS cells[2].
8-Hydroxyquinoline (mixture of CuCl2 at 1-5 μM, 2-12 hour) inhibits proteasomal chymotrypsin-like activity[2].
8-Hydroxyquinoline (0-100 μM, 30 min) acts to inhibit inflammation through inhibition of NO production and iNOS expression through blockade of C/EBPb DNA-binding activity and NF-jB activation in Raw 264.7 cells[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

8-Hydroxyquinoline Related Antibodies

Cell Viability Assay[2]

Cell Line: DCIS cells
Concentration: 1,2.5,5,10,20 μM
Incubation Time: 1 or 8 hour
Result: Binding to copper and form complexes make the cells rounded up and detached, induces cell death with in a concentration- and time-dependent manner.
8-OHQ- and CQ-Cu, but not mixture of their analogues and Cu, could induce cancer cell death in a concentration- and time-dependent manner.

Western Blot Analysis[2]

Cell Line: DCIS cells
Concentration: 1,2.5,5 μM
Incubation Time: 0,2,4,8,12 hours
Result: Mixture of CuCl2 inhibited the CT-like activity in a concentration- and time-dependent manner.
Mixture of CuCl2 decreased proteasomal activity and increased ubquititinated proteins and Bax accumulated in a time-dependent manner.

RT-PCR[3]

Cell Line: Lipopolysaccharides (HY-D1056)-stimulated Raw 264.7 cells
Concentration: 25,50,75,100 μM
Incubation Time: 30 min
Result: Inhibited of LPS-induced NO and iNOS expression.br/> Inhibits transcription of iNOS.
Had not affect phosphorylation of MAPKs.
Inhibited NF-jB-binding activity and C/EBPb-binding activity.
In Vivo

8-Hydroxyquinoline (HOQ) (25-100 mg/kg, i.p.,single dose) results in a significant dose-related increase in the number of micronucleated polychromatic erythrocytes (MPCE) in CD1 mice[4].
8-Hydroxyquinoline (8-HQ) (0.3%, skin administration, 4 times weekly) causes depigmented hair to grow in patterns which change with time in mice[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CD1 mice[4]
Dosage: 25,50,100 mg/kg
Administration: Intraperitoneal injection (i.p.)
Result: Resulted in a significant dose-related increase in the number of micronucleated polychromatic erythrocytes (MPCE) at the 24 h samplingtime for all doses tested.
Animal Model: C57BL mice[5]
Dosage: 0.3% 4 times weekly
Administration: Skin administration
Result: Caused depigmented hair to grow in patterns which change with time.
Sufficiently frequent applications result in virtually complete depigmentation in young adult C57BL female mice, while single application causes isolated bands of depigmented hair.
Molecular Weight

145.16

Appearance

Solid

Formula

C9H7NO
CAS No.
SMILES

OC1=C2N=CC=CC2=CC=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (344.45 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.8889 mL 34.4447 mL 68.8895 mL
5 mM 1.3778 mL 6.8889 mL 13.7779 mL
10 mM 0.6889 mL 3.4445 mL 6.8889 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (17.22 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (17.22 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (17.22 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.99%

COA (256 KB) RP-HPLC (256 KB)

Handling Instructions (2659 KB)
References
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8-Hydroxyquinoline Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

8-Hydroxyquinoline148-24-38-QuinolinolBacterialAntibioticInhibitorinhibitorinhibit

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