B7-H4 Protein, Rat (HEK293, His)

The B7-H4 protein acts as a negative regulator, inhibiting T cell activation, proliferation, cytokine production, and cytotoxicity. When expressed on tumor macrophages, it cooperates with regulatory T cells (Tregs) to suppress tumor-associated antigen-specific T cell immunity and create an immunosuppressive microenvironment. B7-H4 Protein, Rat (HEK293, His) is the recombinant rat-derived B7-H4 protein, expressed by HEK293 , with C-His labeled tag. The total length of B7-H4 Protein, Rat (HEK293, His) is 228 a.a., with molecular weight of ~26.6 kDa.

B7-H4 protein functions as a negative regulator of T-cell-mediated immune responses by effectively suppressing T-cell activation, proliferation, cytokine production, and the development of cytotoxicity. Particularly noteworthy is its role when expressed on the cell surface of tumor macrophages, where it collaborates with regulatory T-cells (Treg) to suppress tumor-associated antigen-specific T-cell immunity. This dual action underscores its significance in creating an immunosuppressive microenvironment. Furthermore, B7-H4 is implicated in promoting epithelial cell transformation, suggesting its involvement in processes associated with altered cellular states and potential implications in the context of pathological conditions.

Rat

HEK293

C-His

Q501W4 (F29-S256)

295322  [NCBI]

Approximately 26.6 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.