2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. N7-Methyl-guanosine-5'-triphosphate-5'-adenosine diammonium

N7-Methyl-guanosine-5'-triphosphate-5'-adenosine diammonium  (Synonyms: m7GpppA diammonium)

Cat. No.: HY-139100B Purity: 98.82%
COA Handling Instructions

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N7-Methyl-guanosine-5'-triphosphate-5'-adenosine (m7GpppA) diammonium is a dinucleotide cap analog that can be used for in vitro RNA transcription.

For research use only. We do not sell to patients.

Guanosine 5′-(tetrahydrogen triphosphate), 7-methyl-, inner salt, P′′→5′-ester with adenosine, diammonium salt

N7-Methyl-guanosine-5'-triphosphate-5'-adenosine diammonium Chemical Structure

CAS No. : 75252-10-7

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1 mg USD 477 In-stock
5 mg USD 1050 In-stock
10 mg USD 1680 In-stock
50 mg USD 4800 In-stock
100 mg USD 7600 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of N7-Methyl-guanosine-5'-triphosphate-5'-adenosine diammonium:

N7-Methyl-guanosine-5'-triphosphate-5'-adenosine diammonium Related Antibodies

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Description

N7-Methyl-guanosine-5'-triphosphate-5'-adenosine (m7GpppA) diammonium is a dinucleotide cap analog that can be used for in vitro RNA transcription[1].

Molecular Weight

820.49

Formula

C21H35N12O17P3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=P([O-])(OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C=NC(C2=NC=N3)=C3N)O1)OP(OP(OC[C@H]4O[C@@H](N5C(N=C(N6)N)=C([N+](C)=C5)C6=O)[C@H](O)[C@@H]4O)([O-])=O)([O-])=O.[NH4+].[NH4+]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (60.94 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2188 mL 6.0939 mL 12.1878 mL
5 mM 0.2438 mL 1.2188 mL 2.4376 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 98.82%

COA (249 KB) HNMR (200 KB) CNMR (457 KB) RP-HPLC (338 KB) LCMS (580 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.2188 mL 6.0939 mL 12.1878 mL 30.4696 mL
5 mM 0.2438 mL 1.2188 mL 2.4376 mL 6.0939 mL
10 mM 0.1219 mL 0.6094 mL 1.2188 mL 3.0470 mL
15 mM 0.0813 mL 0.4063 mL 0.8125 mL 2.0313 mL
20 mM 0.0609 mL 0.3047 mL 0.6094 mL 1.5235 mL
25 mM 0.0488 mL 0.2438 mL 0.4875 mL 1.2188 mL
30 mM 0.0406 mL 0.2031 mL 0.4063 mL 1.0157 mL
40 mM 0.0305 mL 0.1523 mL 0.3047 mL 0.7617 mL
50 mM 0.0244 mL 0.1219 mL 0.2438 mL 0.6094 mL
60 mM 0.0203 mL 0.1016 mL 0.2031 mL 0.5078 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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N7-Methyl-guanosine-5'-triphosphate-5'-adenosine diammonium Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

N7-Methyl-guanosine-5'-triphosphate-5'-adenosine diammonium75252-10-7m7GpppA diammoniumDNA/RNA SynthesisRNA transcriptionInhibitorinhibitorinhibit

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