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  4. 5'-Phosphoguanylyl-(3',5')-guanosine

5'-Phosphoguanylyl-(3',5')-guanosine  (Synonyms: pGpG)

Cat. No.: HY-137662 Purity: ≥90.0%
COA Handling Instructions

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5'-Phosphoguanylyl-(3',5')-guanosine (pGpG) is an intermediate molecule produced by the pathway for enzymatic cyclic diguanylate (c-di-GMP) degradation. 5'-Phosphoguanylyl-(3',5')-guanosine can be used to detect the metabolism of nucleic acids.

For research use only. We do not sell to patients.

5'-Phosphoguanylyl-(3',5')-guanosine Chemical Structure

5'-Phosphoguanylyl-(3',5')-guanosine Chemical Structure

CAS No. : 33008-99-0

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1 mg USD 210 In-stock
5 mg USD 480 In-stock
10 mg USD 680 In-stock
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Based on 1 publication(s) in Google Scholar

5'-Phosphoguanylyl-(3',5')-guanosine Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

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  • Customer Review

Description

5'-Phosphoguanylyl-(3',5')-guanosine (pGpG) is an intermediate molecule produced by the pathway for enzymatic cyclic diguanylate (c-di-GMP) degradation. 5'-Phosphoguanylyl-(3',5')-guanosine can be used to detect the metabolism of nucleic acids[1][2].

In Vitro

5'-Phosphoguanylyl-(3',5')-guanosine reduces the rate of c-di-GMP degradation in cell lysates and inhibits the activity of EAL-dependent PDEs (PA2133, PvrR, and purified recombinant RocR) from P. aeruginosa[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

5'-Phosphoguanylyl-(3',5')-guanosine Related Antibodies
Molecular Weight

708.43

Formula

C20H26N10O15P2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@H]([C@@H]1O[P](OC[C@H]([C@H]2O)O[C@](N3C(NC(N)=NC4=O)=C4N=C3)([H])[C@@H]2O)(O)=O)[C@](O[C@@H]1CO[P](O)(O)=O)([H])N5C(NC(N)=NC6=O)=C6N=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, stored under nitrogen, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (70.58 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4116 mL 7.0579 mL 14.1157 mL
5 mM 0.2823 mL 1.4116 mL 2.8231 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 90.37%

COA (259 KB) RP-HPLC (279 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.4116 mL 7.0579 mL 14.1157 mL 35.2893 mL
5 mM 0.2823 mL 1.4116 mL 2.8231 mL 7.0579 mL
10 mM 0.1412 mL 0.7058 mL 1.4116 mL 3.5289 mL
15 mM 0.0941 mL 0.4705 mL 0.9410 mL 2.3526 mL
20 mM 0.0706 mL 0.3529 mL 0.7058 mL 1.7645 mL
25 mM 0.0565 mL 0.2823 mL 0.5646 mL 1.4116 mL
30 mM 0.0471 mL 0.2353 mL 0.4705 mL 1.1763 mL
40 mM 0.0353 mL 0.1764 mL 0.3529 mL 0.8822 mL
50 mM 0.0282 mL 0.1412 mL 0.2823 mL 0.7058 mL
60 mM 0.0235 mL 0.1176 mL 0.2353 mL 0.5882 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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5'-Phosphoguanylyl-(3',5')-guanosine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

5'-Phosphoguanylyl-(3',5')-guanosine33008-99-0pGpGOthersintermediateenzymaticcyclicdiguanylatec-di-GMPInhibitorinhibitorinhibit

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