GR 64349
Based on 1 Customer Validation
GR 64349 is a potent and highly selective NK2 receptor peptide agonist, with an EC50 of 3.7 nM in rat colon. GR 64349 exhibits selectivity >1000 and >300-fold with respect to NK1 and NK3 receptors, respectively.
For research use only. We do not sell to patients.
- Purity: 99.12%
- CAS No.: 137593-52-3
- Formula: C42H68N10O11S
- Molecular Weight:921.11
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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NK2R |
Chemical Information
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CAS No. 137593-52-3
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Appearance Solid
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Molecular Weight 921.11
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Formula C42H68N10O11S
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Color White to off-white
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Sequence
Lys-Asp-Ser-Phe-Val-{Aaa}-Leu-Met-NH2
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Sequence Shortening
KDSFV{Aaa}LM-NH2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H2O : ≥ 50 mg/mL (54.28 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Y Chang, et al. Tachykinin receptor subtypes in the isolated guinea pig heart and their role in mediating responses to neurokinin A. J Pharmacol Exp Ther. 2000 Jul;294(1):147-54. [Content Brief]
[2]. M J Deal, et al. Conformationally constrained tachykinin analogues: potent and highly selective neurokinin NK-2 receptor agonists. J Med Chem. 1992 Oct 30;35(22):4195-204. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.0856 mL | 5.4282 mL | 10.8565 mL | 27.1412 mL |
| 5 mM | 0.2171 mL | 1.0856 mL | 2.1713 mL | 5.4282 mL | |
| 10 mM | 0.1086 mL | 0.5428 mL | 1.0856 mL | 2.7141 mL | |
| 15 mM | 0.0724 mL | 0.3619 mL | 0.7238 mL | 1.8094 mL | |
| 20 mM | 0.0543 mL | 0.2714 mL | 0.5428 mL | 1.3571 mL | |
| 25 mM | 0.0434 mL | 0.2171 mL | 0.4343 mL | 1.0856 mL | |
| 30 mM | 0.0362 mL | 0.1809 mL | 0.3619 mL | 0.9047 mL | |
| 40 mM | 0.0271 mL | 0.1357 mL | 0.2714 mL | 0.6785 mL | |
| 50 mM | 0.0217 mL | 0.1086 mL | 0.2171 mL | 0.5428 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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