2. Immunology/Inflammation
  3. STING IFNAR
  4. diABZI-V/C-DBCO

diABZI-V/C-DBCO is a STING agonist with an EC50 of 1.47 nM. diABZI-V/C-DBCO activates the STING pathway, induces the production of IFN-I, and stimulates the secretion of IFN-β. diABZI-V/C-DBCO serves as a substrate for cathepsin B, and releases active diABZI-amine via cathepsin B-mediated cleavage. In an orthotopic mouse model of breast cancer, diABZI-V/C-DBCO increases serum IFN-β levels and the frequency of granzyme B+ CD8+ T cells. diABZI-V/C-DBCO is applicable to research related to triple-negative breast cancer.

For research use only. We do not sell to patients.

diABZI-V/C-DBCO

diABZI-V/C-DBCO Chemical Structure

CAS No. : 3035557-60-6

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Based on 1 publication(s) in Google Scholar

diABZI-V/C-DBCO Related Antibodies

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Description

diABZI-V/C-DBCO is a STING agonist with an EC50 of 1.47 nM. diABZI-V/C-DBCO activates the STING pathway, induces the production of IFN-I, and stimulates the secretion of IFN-β. diABZI-V/C-DBCO serves as a substrate for cathepsin B, and releases active diABZI-amine via cathepsin B-mediated cleavage. In an orthotopic mouse model of breast cancer, diABZI-V/C-DBCO increases serum IFN-β levels and the frequency of granzyme B+ CD8+ T cells. diABZI-V/C-DBCO is applicable to research related to triple-negative breast cancer[1].

In Vitro

diABZI-V/C-DBCO (0.000001-100 μM, 24 h) activates the STING pathway in THP1-Dual cells with an EC50 of 1.47 nM, and induces the production of type I interferon (IFN-I)[1].
diABZI-V/C-DBCO (0.001-100 μM, 24 h) stimulates mouse splenocytes to secrete beta interferon (IFN-β), with an EC50 of 7.7 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

diABZI-V/C-DBCO Related Antibodies

ELISA Assay[1]

Cell Line: mouse splenocytes
Concentration: 0.001, 0.01, 1, 10, 100 μM
Incubation Time: 24 h
Result: Stimulated mouse splenocytes to secrete beta interferon (IFN-β), with an EC50 of 7.7 μM
In Vivo

diABZI-V/C-DBCO (0.68 mg/kg; i.v.; single/3 doses; once every 4 days) increases serum IFN-β levels and elevates the frequency of granzyme B+ CD8+ T cells in orthotopic breast cancer mouse models[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 (female, 7 weeks old, EO771 breast cancer cell inoculation model)[1]
Dosage: 0.009 μmol/mouse (0.68 mg/kg)
Administration: i.v.; single dose/3 doses; once every 4 days
Result: Failed to significantly upregulate STING-related genes (Ifnb1, Cxcl10, Tmem173, Tnf, Il6) in tumor tissue relative to PBS control.
Increased serum IFN-β levels relative to PBS but lower than levels induced by SAPCon[100 kDa].
Increased the frequency of granzyme B+ CD8+ T cells relative to PBS.
Molecular Weight

1500.66

Formula

C78H89N19O13
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CCN1N=C(C=C1C(NC2=NC3=C(N2C/C=C/CN4C(NC(C5=CC(C)=NN5CC)=O)=NC6=CC(C(N)=O)=CC(OC)=C64)C(OCCCNC(OCC7=CC=C(C=C7)NC([C@@H](NC([C@H](C(C)C)NC(CCCCC(N8CC9=C(C=CC=C9)C#CC%10=C8C=CC=C%10)=O)=O)=O)CCCNC(N)=O)=O)=O)=CC(C(N)=O)=C3)=O)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (66.64 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.6664 mL 3.3319 mL 6.6637 mL
5 mM 0.1333 mL 0.6664 mL 1.3327 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.66%

SDS (252 KB)

COA (253 KB) HNMR (458 KB) RP-HPLC (276 KB) LCMS (88 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.6664 mL 3.3319 mL 6.6637 mL 16.6593 mL
5 mM 0.1333 mL 0.6664 mL 1.3327 mL 3.3319 mL
10 mM 0.0666 mL 0.3332 mL 0.6664 mL 1.6659 mL
15 mM 0.0444 mL 0.2221 mL 0.4442 mL 1.1106 mL
20 mM 0.0333 mL 0.1666 mL 0.3332 mL 0.8330 mL
25 mM 0.0267 mL 0.1333 mL 0.2665 mL 0.6664 mL
30 mM 0.0222 mL 0.1111 mL 0.2221 mL 0.5553 mL
40 mM 0.0167 mL 0.0833 mL 0.1666 mL 0.4165 mL
50 mM 0.0133 mL 0.0666 mL 0.1333 mL 0.3332 mL
60 mM 0.0111 mL 0.0555 mL 0.1111 mL 0.2777 mL
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diABZI-V/C-DBCO Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

diABZI-V/C-DBCO3035557-60-6STINGIFNARStimulator of Interferon GenesTMEM173MITAERISMPYSInterferon-α/β receptorInterferon-alpha/beta receptorSTING agonistTHP1-Dual reporter cellstriple-negative breast cancermouse splenocytesC57BL/6 miceInhibitorinhibitorinhibit

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