m7G(5')ppp(5')(2'OMeA)pU ammonium solution (100 mM)
Based on 1 Customer Validation
m7G(5')ppp(5')(2'OMeA)pU (ammonium) solution (100 mM) is a trinucleotide cap analog with a Cap1 structure. m7G(5')ppp(5')(2'OMeA)pU (ammonium) solution (100 mM) can be co-transcriptionally incorporated into the 5' end of mRNA during T7 RNA polymerase-mediated in vitro transcription to form a natural Cap1 cap structure. m7G(5')ppp(5')(2'OMeA)pU (ammonium) solution (100 mM) enhances mRNA translation efficiency and reduces innate immune recognition, and it has been used in the preparation of self-amplifying mRNA rabies vaccines. m7G(5')ppp(5')(2'OMeA)pU (ammonium) solution (100 mM) can be applied to research related to in vitro mRNA transcription and mRNA vaccines.
For research use only. We do not sell to patients.
- Purity: 99.6%
- Formula: C31H42N12O25P4.xNH3
- Molecular Weight:1106.63 (free acid)
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
CAP GAU m7G (5') ppp (5')(2'OMeA) pU is used for co-transcriptional capping during in vitro transcription by T7 RNA polymerase, and the self-amplifying mRNA prepared shows an integrity of 86.8%. After encapsulation with LNP, this capped mRNA transfects HEK293T cells and enables dose- and time-dependent expression of RABV-G protein[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Unlabeled Cas C31H42N12O25P4.xNH3
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Appearance Liquid
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Molecular Weight 1106.63 (free acid)
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Formula C31H42N12O25P4.xNH3
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Color Colorless to light yellow
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SMILES
O[C@H]1[C@@H](O)[C@H](N2C(NC(C=C2)=O)=O)O[C@@H]1COP(O[C@H]3[C@@H](OC)[C@H](N4C(N=CN=C5N)=C5N=C4)O[C@@H]3COP([O-])(OP(OP(O)(OC[C@@H]6[C@@H](O)[C@@H](O)[C@H](N7C(N=C(N)NC8=O)=C8[N+](C)=C7)O6)=O)(O)=O)=O)(O)=O.[x].N
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
m7G(5')ppp(5')(2'OMeA)pU ammonium solution (100 mM) Related Classifications
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