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Cat. No.: HY-178671

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CAP GAU m7G(5')ppp(5')(2'OMeA)pU

CAP GAU m7G (5') ppp (5')(2'OMeA) pU is a trinucleotide cap analog with a Cap1 structure. CAP GAU m7G (5') ppp (5')(2'OMeA) pU can be co-transcriptionally incorporated into the 5' end of mRNA during T7 RNA polymerase-mediated in vitro transcription to form a natural Cap1 cap structure. CAP GAU m7G (5') ppp (5')(2'OMeA) pU enhances mRNA translation efficiency and reduces innate immune recognition, and it has been used in the preparation of self-amplifying mRNA rabies vaccines. CAP GAU m7G (5') ppp (5')(2'OMeA) pU can be applied to research related to in vitro mRNA transcription and mRNA vaccines.

For research use only. We do not sell to patients.

CAS No.: 2734858-38-7
Formula: C₃₁H₄₂N₁₂O₂₅P₄
Molecular Weight:1106.63

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

CAP GAU m7G(5')ppp(5')(2'OMeA)pU Chemical Structure

CAS No.: 2734858-38-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

All DNA/RNA Synthesis Isoforms :

In Vitro

CAP GAU m7G (5') ppp (5')(2'OMeA) pU is used for co-transcriptional capping during in vitro transcription by T7 RNA polymerase, and the self-amplifying mRNA prepared shows an integrity of 86.8%. After encapsulation with LNP, this capped mRNA transfects HEK293T cells and enables dose- and time-dependent expression of RABV-G protein^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2734858-38-7
Molecular Weight 1106.63
Formula C₃₁H₄₂N₁₂O₂₅P₄
SMILES

O[C@H]1[C@@H](O)[C@H](N2C(NC(N)=NC3=O)=C3[N+](C)=C2)O[C@@H]1COP(OP(OP(OC[C@@H]4O[C@H](N5C6=NC=NC(N)=C6N=C5)[C@@H](OC)[C@H]4OP(OC[C@@H]7[C@@H](O)[C@@H](O)[C@H](N8C(NC(C=C8)=O)=O)O7)(O)=O)(O)=O)(O)=O)([O-])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhao D, et al. A single ultra-low dose self-amplifying RNA rabies vaccine confers rapid and complete protection in mice. Vaccine. 2026 Feb 15;73:128150.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References

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CAP GAU m7G(5')ppp(5')(2'OMeA)pU

All DNA/RNA Synthesis Isoforms