1. Anti-infection
  2. HIV
    Reverse Transcriptase

GS-7340 fumarate (Synonyms: Tenofovir alafenamide fumarate)

Cat. No.: HY-15232A Purity: 99.86%
Handling Instructions

GS-7340(Tenofovir alafenamide) is a prodrug of tenofovir (TFV) that more efficiently delivers TFV into lymphoid cells and tissues than TFV disoproxil fumarate.

For research use only. We do not sell to patients.

GS-7340 fumarate Chemical Structure

GS-7340 fumarate Chemical Structure

CAS No. : 379270-38-9

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 65 In-stock
Estimated Time of Arrival: December 31
5 mg USD 50 In-stock
Estimated Time of Arrival: December 31
10 mg USD 70 In-stock
Estimated Time of Arrival: December 31
50 mg USD 140 In-stock
Estimated Time of Arrival: December 31
100 mg USD 190 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Other Forms of GS-7340 fumarate:

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

GS-7340(Tenofovir alafenamide) is a prodrug of tenofovir (TFV) that more efficiently delivers TFV into lymphoid cells and tissues than TFV disoproxil fumarate. IC50 value: Target: NRTI; HIV reverse transcriptase inhibitor GS-7340 reduces first-pass clearance to be an effective oral prodrug, its permeability and stability were characterized in vitro and detailed pharmacokinetic studies were completed in dogs. GS-7340 showed concentration-dependent permeability through monolayers of caco-2 cells and dose-dependent oral bioavailability in dogs, increasing from 1.7% at 2 mg/kg to 24.7% at 20 mg/kg, suggesting saturable intestinal efflux transport [1]. Significant reductions in plasma HIV-1 RNA from baseline to day 11 were observed for all TAF dose groups compared with placebo (P < 0.01), with a median decrease of 1.08-1.73 log10 copies per milliliter, including a dose-response relationship for viral load decrease up to 25 mg [2].

Clinical Trial
Solvent & Solubility
In Vitro: 

DMSO : ≥ 36 mg/mL (60.76 mM)

H2O : ≥ 25 mg/mL (42.19 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6876 mL 8.4382 mL 16.8765 mL
5 mM 0.3375 mL 1.6876 mL 3.3753 mL
10 mM 0.1688 mL 0.8438 mL 1.6876 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

592.54

Formula

C₂₅H₃₃N₆O₉P

CAS No.

379270-38-9

SMILES

NC1=NC=NC2=C1N=CN2C[[email protected]@H](C)OC[[email protected]](OC3=CC=CC=C3)(N[[email protected]@H](C)C(OC(C)C)=O)=O.O=C(O)/C=C/C(O)=O

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Purity: 99.86%

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
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Product Name:
GS-7340 fumarate
Cat. No.:
HY-15232A
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GS-7340 fumarate

Cat. No.: HY-15232A