1. Anti-infection
  2. HIV
    Reverse Transcriptase
  3. Rilpivirine

Rilpivirine (Synonyms: R278474; TMC278; DB08864)

Cat. No.: HY-10574 Purity: 99.84%
Handling Instructions

Rilpivirine (R278474; TMC278) is a type of anti-HIV medicine called a non-nucleoside reverse transcriptase inhibitor (NNRTI).

For research use only. We do not sell to patients.

Rilpivirine Chemical Structure

Rilpivirine Chemical Structure

CAS No. : 500287-72-9

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 207 In-stock
Estimated Time of Arrival: December 31
10 mg USD 188 In-stock
Estimated Time of Arrival: December 31
50 mg USD 473 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Customer Review

Based on 4 publication(s) in Google Scholar

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Description

Rilpivirine (R278474; TMC278) is a type of anti-HIV medicine called a non-nucleoside reverse transcriptase inhibitor (NNRTI).

IC50 & Target

NNRTIs

In Vitro

Rilpivirine(TMC278) is a next-generation nonnucleoside reverse transcriptase inhibitor (NNRTI), active against wild-type and NNRTI-resistant HIV-1. NNRTIs work by binding to and blocking HIV reverse transcriptase, an HIV enzyme. This prevents HIV from replicating and lowers the amount of HIV in the blood.

Clinical Trial
Molecular Weight

366.42

Formula

C₂₂H₁₈N₆

CAS No.

500287-72-9

SMILES

CC1=CC(/C=C/C#N)=CC(C)=C1NC2=CC=NC(NC3=CC=C(C=C3)C#N)=N2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (136.46 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7291 mL 13.6455 mL 27.2911 mL
5 mM 0.5458 mL 2.7291 mL 5.4582 mL
10 mM 0.2729 mL 1.3646 mL 2.7291 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 3 mg/mL (8.19 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 3 mg/mL (8.19 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 3 mg/mL (8.19 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.84%

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Keywords:

RilpivirineR278474TMC278DB08864R 278474R-278474TMC 278TMC-278DB 08864DB-08864HIVReverse TranscriptaseHuman immunodeficiency virusInhibitorinhibitorinhibit

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Rilpivirine
Cat. No.:
HY-10574
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