1051375-13-3
Chemical Structure
Cabotegravir sodium
Synonym(s): GSK-1265744 sodium; S/GSK1265744 sodium
- CAS 番号: 1051375-13-3
- Formula:C19H16F2N3NaO5
- Molecular Weight:427.33
IUPAC Name: sodium (3S,11aR)-8-((2,4-difluorobenzyl)carbamoyl)-3-methyl-5,7-dioxo-2,3,5,7,11,11a-hexahydrooxazolo[3,2-a]pyrido[1,2-d]pyrazin-6-olate
InChIKey: AEZBWGMXBKPGFP-KIUAEZIZSA-M
SMILES: FC1=C(CNC(C2=CN3C(C(N([C@@H](C)CO4)[C@@]4([H])C3)=O)=C(O[Na])C2=O)=O)C=CC(F)=C1
Biological Activity: Cabotegravir (GSK-1265744) sodium is a orally active and long-acting HIV integrase strand transfer inhibitor and organic anion transporter 1/3 (OAT1/OAT3) inhibitor with IC50 values of 2.5 nM, 0.41 μM and 0.81 μM for HIVADA, OAT3 and OAT1, respectively. Cabotegravir sodium is primarily metabolized by uridine diphosphate glucuronosyltransferase (UGT) 1A1, with low potential to interact with other antiretroviral agents (ARVs). Cabotegravir sodium can be used to research AIDS[1][2].
| 製品番号 | 製品名 | 純度 | 製品説明 | Pricing | |||||||||||||||||||
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Cabotegravir sodium | 99.87% | Cabotegravir (GSK-1265744) sodium is a orally active and long-acting HIV integrase strand transfer inhibitor and organic anion transporter 1/3 (OAT1/OAT3) inhibitor with IC50 values of 2.5 nM, 0.41 μM and 0.81 μM for HIVADA, OAT3 and OAT1, respectively. Cabotegravir sodium is primarily metabolized by uridine diphosphate glucuronosyltransferase (UGT) 1A1, with low potential to interact with other antiretroviral agents (ARVs). Cabotegravir sodium can be used to research AIDS. | ||||||||||||||||||||
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Cabotegravir-d3 sodium | Cabotegravir-d3 (sodium) is the deuterium labeled Cabotegravir sodium. Cabotegravir sodium is a highly potent HIV integrase inhibitor with an IC50 value of 2.5 nM for HIVADA. Cabotegravir sodium is primarily metabolized by uridine diphosphate glucuronosyltr | |||||||||||||||||||||
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Similarity Score 0.89
HY-13238ADolutegravir sodium -
Similarity Score 0.87
HY-15592Cabotegravir -
Similarity Score 0.79
HY-13238Dolutegravir -
Similarity Score 0.79
HY-W7819664-epi-Dolutegravir -
Similarity Score 0.73
HY-177071Asuptegravir -
Similarity Score 0.71
HY-15592S1Cabotegravir-d5 -
Similarity Score 0.70
HY-17605ABictegravir sodium -
Similarity Score 0.67
HY-138011Dolutegravir O-β-D-glucuronide -
Similarity Score 0.66
HY-162253HIV-1 inhibitor-64 -
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References
- [1]. Zhou T, et al. Creation of a nanoformulated cabotegravir prodrug with improved antiretroviral profiles. Biomaterials. 2018 Jan;151:53-65. [Content Brief]
- [2]. Reese MJ, et al. Drug interaction profile of the HIV integrase inhibitor cabotegravir: assessment from in vitro studies and a clinical investigation with midazolam. Xenobiotica. 2016;46(5):445-56. [Content Brief]
