Salicylanilide
Based on 5 publication(s) in Google Scholar
Salicylanilide demonstrates a wide range of biological activities including antiviral potency which can inhibit HIV virus by targeting HIV-1 integrase or reverse transcriptase.
For research use only. We do not sell to patients.
- Purity: 98.14%
- CAS No.: 87-17-2
- Formula: C13H11NO2
- Molecular Weight:213.23
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Salicylanilide
More
Biological Activity
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HIV-1 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | CC50 |
>100 μM
Compound: 16
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Cytotoxicity against HEK293 cells assessed as reduction in cell viability after 48 hrs by Alamar Blue reporter assay
Cytotoxicity against HEK293 cells assessed as reduction in cell viability after 48 hrs by Alamar Blue reporter assay
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[PMID: 30392371] |
| HepG2 | IC50 |
89.8 μM
Compound: SAL-5
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Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 24 hrs by MTS assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 24 hrs by MTS assay
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[PMID: 24953953] |
Some Salicylanilides and salicylamides could inhibit HIV virus by targeting of HIV-1 integrase or reverse transcriptase. Hepatitis C virus is another virus, which can be potentially afflicted by Salicylanilides on the level of two enzymes-NS3 protease and NS5B RNA polymerase[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 87-17-2
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Appearance Solid
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Molecular Weight 213.23
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Formula C13H11NO2
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Color Light brown to brown
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SMILES
O=C(NC1=CC=CC=C1)C2=CC=CC=C2O
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Synonyms
2-Hydroxybenzanilide
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (5)
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Journal Impact Factor
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Most Recent
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Drug Deliv Transl Res
Leveraging quantum chemical properties in transfer learning for predicting blood-brain barrier permeability of drugs. [Abstract]2025 Oct 29. PMID: 41160380 -
Int J Antimicrob Agents
2019 Dec;54(6):814-819. PMID: 31479744 -
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Solvent & Solubility
DMSO : 170 mg/mL (797.26 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (597 KB)
- English - EN (597 KB)
- Français - FR (597 KB)
- Deutsch - DE (597 KB)
- Norwegian - NO (597 KB)
- Español - ES (597 KB)
- Swedish - SV (597 KB)
- Italian - IT (597 KB)
- Portuguese - PT (597 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.6898 mL | 23.4489 mL | 46.8977 mL | 117.2443 mL |
| 5 mM | 0.9380 mL | 4.6898 mL | 9.3795 mL | 23.4489 mL | |
| 10 mM | 0.4690 mL | 2.3449 mL | 4.6898 mL | 11.7244 mL | |
| 15 mM | 0.3127 mL | 1.5633 mL | 3.1265 mL | 7.8163 mL | |
| 20 mM | 0.2345 mL | 1.1724 mL | 2.3449 mL | 5.8622 mL | |
| 25 mM | 0.1876 mL | 0.9380 mL | 1.8759 mL | 4.6898 mL | |
| 30 mM | 0.1563 mL | 0.7816 mL | 1.5633 mL | 3.9081 mL | |
| 40 mM | 0.1172 mL | 0.5862 mL | 1.1724 mL | 2.9311 mL | |
| 50 mM | 0.0938 mL | 0.4690 mL | 0.9380 mL | 2.3449 mL | |
| 60 mM | 0.0782 mL | 0.3908 mL | 0.7816 mL | 1.9541 mL | |
| 80 mM | 0.0586 mL | 0.2931 mL | 0.5862 mL | 1.4656 mL | |
| 100 mM | 0.0469 mL | 0.2345 mL | 0.4690 mL | 1.1724 mL |
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