LEDGIN6
Based on 4 publication(s) in Google Scholar
LEDGIN6 (CX05168) is a quinoline-based protein-protein interaction inhibitor of LEDGF/p75 and HIV integrase.
For research use only. We do not sell to patients.
- Purity: 99.62%
- CAS No.: 957890-42-5
- Formula: C21H20ClNO2
- Molecular Weight:353.84
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
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Help & FAQs
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Bioactive Compound Library Max
HY-L181
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Bioactive Compound Library
HY-L001
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Anti-Infection Compound Library
HY-L002
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Metabolism/Protease Compound Library
HY-L012
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Antiviral Compound Library
HY-L027
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Targeted Diversity Library
HY-L099
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Protein-protein Interaction Inhibitor Library
HY-L109
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Heterocyclic Compound Library
HY-L138
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Metabolic Enzyme Compound Library
HY-L146
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Multi-Target Compound Library
HY-L176
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MCE Bioactive Compound Library
HY-L001V
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High-Throughput Bioactive Compound Library
HY-L205
Publications Citing Use of MedChemExpress (MCE) LEDGIN6
More
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MT4 | CC50 |
67.3 μM
Compound: CX04328
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Cytotoxicity against human MT4 cells by MTT assay
Cytotoxicity against human MT4 cells by MTT assay
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10.1039/C3MD00302G |
| MT4 | EC50 |
2.35 μM
Compound: CX04328
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Antiviral activity against HIV1 3B infected in human MT4 cells assessed as inhibition of viral replication by MTT assay
Antiviral activity against HIV1 3B infected in human MT4 cells assessed as inhibition of viral replication by MTT assay
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10.1039/C3MD00302G |
Chemical Information
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CAS No. 957890-42-5
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Appearance Solid
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Molecular Weight 353.84
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Formula C21H20ClNO2
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Color Light yellow to yellow
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SMILES
ClC1=CC=C(N=C(C)C(C(CCC)C(O)=O)=C2C3=CC=CC=C3)C2=C1
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Synonyms
CX05168; CX04328
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (4)
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Journal Impact Factor
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Most Recent
Solvent & Solubility
DMSO : ≥ 100 mg/mL (282.61 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (7.07 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (248 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.8261 mL | 14.1307 mL | 28.2614 mL | 70.6534 mL |
| 5 mM | 0.5652 mL | 2.8261 mL | 5.6523 mL | 14.1307 mL | |
| 10 mM | 0.2826 mL | 1.4131 mL | 2.8261 mL | 7.0653 mL | |
| 15 mM | 0.1884 mL | 0.9420 mL | 1.8841 mL | 4.7102 mL | |
| 20 mM | 0.1413 mL | 0.7065 mL | 1.4131 mL | 3.5327 mL | |
| 25 mM | 0.1130 mL | 0.5652 mL | 1.1305 mL | 2.8261 mL | |
| 30 mM | 0.0942 mL | 0.4710 mL | 0.9420 mL | 2.3551 mL | |
| 40 mM | 0.0707 mL | 0.3533 mL | 0.7065 mL | 1.7663 mL | |
| 50 mM | 0.0565 mL | 0.2826 mL | 0.5652 mL | 1.4131 mL | |
| 60 mM | 0.0471 mL | 0.2355 mL | 0.4710 mL | 1.1776 mL | |
| 80 mM | 0.0353 mL | 0.1766 mL | 0.3533 mL | 0.8832 mL | |
| 100 mM | 0.0283 mL | 0.1413 mL | 0.2826 mL | 0.7065 mL |
LEDGIN6 Related Classifications
HY-10522 Related Classifications
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