1. Anti-infection
  2. Antibiotic
    Bacterial
  3. Tazobactam

Tazobactam  (Synonyms: CL-298741; YTR-830H)

Cat. No.: HY-B1418 Purity: 99.90%
COA Handling Instructions

Tazobactam (CL-298741) is a potent β-lactamases inhibitor and penicillin antibiotic. Tazobactam has antibacterial activity. Tazobactam can be used for pneumonia research.

For research use only. We do not sell to patients.

Tazobactam Chemical Structure

Tazobactam Chemical Structure

CAS No. : 89786-04-9

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Solution
10 mM * 1 mL in DMSO USD 61 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 61 In-stock
Estimated Time of Arrival: December 31
Solid
100 mg USD 55 In-stock
Estimated Time of Arrival: December 31
200 mg USD 77 In-stock
Estimated Time of Arrival: December 31
500 mg USD 99 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 3 publication(s) in Google Scholar

Other Forms of Tazobactam:

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  • Customer Review

Description

Tazobactam (CL-298741) is a potent β-lactamases inhibitor and penicillin antibiotic. Tazobactam has antibacterial activity. Tazobactam can be used for pneumonia research[1][2].

In Vitro

Tazobactam (CL-298741) (5 μg/mL; 18 hours) has bactericidal activity and inhibit the growth of the bacteria in a dose-dependent manner[2].
Tazobactam (CL-298741) (1-10 μg/mL; 6 hours; Prot. vulgaris and M. morgan) inhibits various types β-lactamase activity and with ID50 values of < 10 μg/mL, respectively[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Tazobactam (CL-298741) (1000 mg/kg; i.p.; four times a day, for 36 and 84 hours; BALB/c mice) decreases the number of bacteria in mice and survived in low doses[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c mice[1]
Dosage: 1000 mg/kg
Administration: Intraperitoneal injection; four times a day, for 36 and 84 hours
Result: Decraesed the number of bacteria and neutrophils in BALF than in the control group.
Clinical Trial
Molecular Weight

300.29

Formula

C10H12N4O5S

CAS No.
SMILES

O=C([[email protected]@H]([[email protected]@](CN1N=NC=C1)(C)S([[email protected]]2([H])C3)(=O)=O)N2C3=O)O

Structure Classification
Source

Gram-negative bacilli

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (166.51 mM; Need ultrasonic)

H2O : 1 mg/mL (3.33 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3301 mL 16.6506 mL 33.3011 mL
5 mM 0.6660 mL 3.3301 mL 6.6602 mL
10 mM 0.3330 mL 1.6651 mL 3.3301 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (6.93 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (6.93 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (6.93 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.90%

References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Tazobactam
Cat. No.:
HY-B1418
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