74469-00-4
Chemical Structure
Amoxicillin-clavulanate potassium
- CAS No.: 74469-00-4
- Formula:C24H27KN4O10S
- Molecular Weight:602.66
InChIKey: DWHGNUUWCJZQHO-ZVDZYBSKSA-M
SMILES: O=C([C@@H]1N2[C@](CC2=O)([H])O/C1=C\CO)O[K].OC([C@@H]3N4[C@]([C@H](NC([C@@H](C5=CC=C(O)C=C5)N)=O)C4=O)([H])SC3(C)C)=O
Biological Activity: Amoxicillin-clavulanate potassium is an orally active antibacterial composition consisting of Amoxicillin (HY-B0467A) and the β-lactamase inhibitor Clavulanate potassium (HY-A0256A). In Amoxicillin-clavulanate potassium, Amoxicillin binds to bacterial penicillin-binding proteins to inhibit peptidoglycan synthesis and exert a bactericidal effect; Clavulanate potassium protects Amoxicillin from hydrolysis by β-lactamase. Amoxicillin-clavulanate potassium exhibits antibacterial activity against β-lactamase-producing Gram-positive and Gram-negative bacteria. Amoxicillin-clavulanate potassium dose-dependently interferes with the function of ameloblasts at the maturation stage, disrupts the enamel mineralization process, and induces enamel developmental defects. Amoxicillin-clavulanate potassium can be used in research related to bacterial infections[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Amoxicillin-clavulanate potassium | 93.62% | Amoxicillin-clavulanate potassium is an orally active antibacterial composition consisting of Amoxicillin (HY-B0467A) and the β-lactamase inhibitor Clavulanate potassium (HY-A0256A). In Amoxicillin-clavulanate potassium, Amoxicillin binds to bacterial penicillin-binding proteins to inhibit peptidoglycan synthesis and exert a bactericidal effect; Clavulanate potassium protects Amoxicillin from hydrolysis by β-lactamase. Amoxicillin-clavulanate potassium exhibits antibacterial activity against β-lactamase-producing Gram-positive and Gram-negative bacteria. Amoxicillin-clavulanate potassium dose-dependently interferes with the function of ameloblasts at the maturation stage, disrupts the enamel mineralization process, and induces enamel developmental defects. Amoxicillin-clavulanate potassium can be used in research related to bacterial infections. | ||||||||||||||||||||
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References
- [1]. Mihalaş E, et al. The Role of Chronic Exposure to Amoxicillin/Clavulanic Acid on the Developmental Enamel Defects in Mice. Toxicologic pathology. 2016 Jan;44(1):61-70.
- [2]. Andes D, et al. In vivo activities of amoxicillin and amoxicillin-clavulanate against Streptococcus pneumoniae: application to breakpoint determinations. Antimicrobial agents and chemotherapy. 1998 Sep;42(9):2375-9. [Content Brief]
- [3]. Benninger MS, et al. Amoxicillin/clavulanate potassium extended release tablets: a new antimicrobial for the treatment of acute bacterial sinusitis and community-acquired pneumonia. Expert opinion on pharmacotherapy. 2003 Oct;4(10):1839-46.
