2. Anti-infection
  3. Bacterial Antibiotic
  4. Aspoxicillin

Aspoxicillin is a broad-spectrum antimicrobial agent against 68 isolates of Actinobacillus pleuropneumoniae with an MIC90 value of <= 0.05 μg/ml. Aspoxicillin has a long half-life in mouse serum of 55 minutes.

For research use only. We do not sell to patients.

Aspoxicillin Chemical Structure

Aspoxicillin Chemical Structure

CAS No. : 63358-49-6

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5 mg USD 43 In-stock
10 mg USD 65 In-stock
25 mg USD 130 In-stock
50 mg USD 210 In-stock
100 mg USD 340 In-stock
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Based on 1 publication(s) in Google Scholar

Aspoxicillin Related Antibodies

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Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Aspoxicillin is a broad-spectrum antimicrobial agent against 68 isolates of Actinobacillus pleuropneumoniae with an MIC90 value of <= 0.05 μg/ml. Aspoxicillin has a long half-life in mouse serum of 55 minutes[1][2].

IC50 & Target

β-lactam

 

In Vitro

Aspoxicillin is a semisynthetic penicillin derivative[2] Aspoxicillin induces postantibiotic effects (PAEs) against Staphylococcus aureus Smith of 1.7 h in vitro[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Aspoxicillin Related Antibodies
In Vivo

Aspoxicillin induces PAEs against Staphylococcus aureus Smith of 5.2 h in vivo in a thigh infection model in neutropenic mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

493.53

Formula

C21H27N5O7S
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C([C@@H](C(C=C1)=CC=C1O)NC([C@H](N)CC(NC)=O)=O)N[C@H]2[C@](SC(C)3C)([H])N(C2=O)[C@H]3C(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 25 mg/mL (50.66 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0262 mL 10.1311 mL 20.2622 mL
5 mM 0.4052 mL 2.0262 mL 4.0524 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 12.5 mg/mL (25.33 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.0262 mL 10.1311 mL 20.2622 mL 50.6555 mL
5 mM 0.4052 mL 2.0262 mL 4.0524 mL 10.1311 mL
10 mM 0.2026 mL 1.0131 mL 2.0262 mL 5.0655 mL
15 mM 0.1351 mL 0.6754 mL 1.3508 mL 3.3770 mL
20 mM 0.1013 mL 0.5066 mL 1.0131 mL 2.5328 mL
25 mM 0.0810 mL 0.4052 mL 0.8105 mL 2.0262 mL
30 mM 0.0675 mL 0.3377 mL 0.6754 mL 1.6885 mL
40 mM 0.0507 mL 0.2533 mL 0.5066 mL 1.2664 mL
50 mM 0.0405 mL 0.2026 mL 0.4052 mL 1.0131 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Aspoxicillin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Aspoxicillin63358-49-6BacterialAntibioticantimicrobialActinobacilluspleuropneumoniaepenicillinInhibitorinhibitorinhibit

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