1. Anti-infection
  2. Bacterial
  3. Aspoxicillin

Aspoxicillin 

Cat. No.: HY-135842
Handling Instructions

Aspoxicillin is a broad-spectrum antimicrobial agent against 68 isolates of Actinobacillus pleuropneumoniae with an MIC90 value of <= 0.05 μg/ml. Aspoxicillin has a long half-life in mouse serum of 55 minutes.

For research use only. We do not sell to patients.

Aspoxicillin Chemical Structure

Aspoxicillin Chemical Structure

CAS No. : 63358-49-6

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Description

Aspoxicillin is a broad-spectrum antimicrobial agent against 68 isolates of Actinobacillus pleuropneumoniae with an MIC90 value of <= 0.05 μg/ml. Aspoxicillin has a long half-life in mouse serum of 55 minutes[1][2].

IC50 & Target

microbe[1]

In Vitro

Aspoxicillin is a semisynthetic penicillin derivative[2] Aspoxicillin induces postantibiotic effects (PAEs) against Staphylococcus aureus Smith of 1.7 h in vitro[2].

In Vivo

Aspoxicillin induces PAEs against Staphylococcus aureus Smith of 5.2 h in vivo in a thigh infection model in neutropenic mice[2].

Molecular Weight

493.53

Formula

C₂₁H₂₇N₅O₇S

CAS No.

63358-49-6

SMILES

O=C(N)[[email protected]@H](C1=CC=C(O)C=C1)N(C([[email protected]@H](CC(N)=O)NC)=O)[[email protected]]2[[email protected]@]3([H])SC(C)(C)[[email protected]](C(O)=O)N3C2=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 25 mg/mL (50.66 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0262 mL 10.1311 mL 20.2622 mL
5 mM 0.4052 mL 2.0262 mL 4.0524 mL
10 mM 0.2026 mL 1.0131 mL 2.0262 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

AspoxicillinBacterialantimicrobialActinobacilluspleuropneumoniaepenicillinInhibitorinhibitorinhibit

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Aspoxicillin
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