Beta-lactamase Substrate

Nitrocefin is a highly activated, chromogenic cephalosporin derivative. Nitrocefin is a chromogenic β-lactamase substrate. Nitrocefin undergoes a distinctive color change from yellow to red as the amide bond in the β-lactam ring is hydrolyzed by β-lactamase. Nitrocefin is used in competitive inhibition studies in developmental work on β-lactamase-resistant antibiotics.

E-0702 is a cephalosporin antibacterial compound containing a catechol moiety. E-0702 chelates ferric ions, enters the intracellular compartment of Gram-negative bacteria via the TonB-dependent iron uptake system, and exerts bactericidal effects by inhibiting penicillin-binding proteins (PBPs). E-0702 exhibits iron-regulated bactericidal activity against Gram-negative bacteria and some Gram-positive bacteria, and possesses broad-spectrum anti-Pseudomonas activity. E-0702 can be hydrolyzed by common β-lactamases. E-0702 can be used in research related to bacterial infections.

Cefcanel is an orally active cephalosporin and antibacterial agent. Cefcanel inhibits growth of methicillin-susceptible Staphylococcus aureus, methicillin-susceptible Staphylococcus epidermidis, Haemophilus influenzae, Moraxella catarrhalis. Cefcanel acts as a substrate hydrolyzed by TEM-1, TEM-3, and Moraxella Bro-1 beta-lactamases.