77768-46-8
Chemical Structure
E-0702
- CAS No.: 77768-46-8
- Formula:C29H23N7O12S2
- Molecular Weight:725.66
InChIKey: IZPIFKHYHHWRMA-LGVUCKNBSA-N
SMILES: OC(C1=C(CSC2=NN=NN2CC(O)=O)CS[C@@]([C@@H]3NC([C@@H](C4=CC=C(C=C4)O)NC(C(C(C5=C6)=O)=COC5=CC(O)=C6O)=O)=O)([H])N1C3=O)=O
Biological Activity: E-0702 is a cephalosporin antibacterial compound containing a catechol moiety. E-0702 chelates ferric ions, enters the intracellular compartment of Gram-negative bacteria via the TonB-dependent iron uptake system, and exerts bactericidal effects by inhibiting penicillin-binding proteins (PBPs). E-0702 exhibits iron-regulated bactericidal activity against Gram-negative bacteria and some Gram-positive bacteria, and possesses broad-spectrum anti-Pseudomonas activity. E-0702 can be hydrolyzed by common β-lactamases. E-0702 can be used in research related to bacterial infections[1][2][3].
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E-0702 | E-0702 is a cephalosporin antibacterial compound containing a catechol moiety. E-0702 chelates ferric ions, enters the intracellular compartment of Gram-negative bacteria via the TonB-dependent iron uptake system, and exerts bactericidal effects by inhibiting penicillin-binding proteins (PBPs). E-0702 exhibits iron-regulated bactericidal activity against Gram-negative bacteria and some Gram-positive bacteria, and possesses broad-spectrum anti-Pseudomonas activity. E-0702 can be hydrolyzed by common β-lactamases. E-0702 can be used in research related to bacterial infections. | |||||||||||||||||||||
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References
- [1]. Lin YM, et al. Synthetic sideromycins (skepticism and optimism): selective generation of either broad or narrow spectrum Gram-negative antibiotics. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. 2019 Jun;32(3):425-451.
- [2]. Neu HC. In vitro antibacterial activity and beta-lactamase stability of E-0702, a new cephalosporin. Antimicrob Agents Chemother. 1983 Sep;24(3):313-20.
- [3]. Watanabe NA, et al. E-0702, a new cephalosporin, is incorporated into Escherichia coli cells via the tonB-dependent iron transport system. Antimicrobial agents and chemotherapy. 1987 Apr;31(4):497-504.
