Relebactam (Synonyms: MK-7655)

Name: Relebactam
Brand: MedChemExpress
SKU: HY-16752
Rating: 5.0 (29 reviews)

Cat. No.: HY-16752 Purity: 99.95%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Relebactam is a diazabicyclooctane inhibitor with activity against a wide spectrum of β-lactamases, including class A (extended-spectrum β-lactamases and KPC) and class C (AmpC) enzymes. Relebactam shows antibacterial activity.

For research use only. We do not sell to patients.

CAS No. : 1174018-99-5

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

or Bulk Inquiry

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 29 publication(s) in Google Scholar

Other Forms of Relebactam:

29 Publications Citing Use of MCE Relebactam

Microbiological Assay

Bio/Physico-chemical Assay

: Relebactam purchased from MedChemExpress. Usage Cited in: Int J Antimicrob Agents. 2024 May 14:107206. [Abstract]; The MultiRapid ATB NP test. Column D shows the solution with imipenem–relebactam (IPR, 12/4 mg/L);. Reference strain Escherichia coli ATCC 25922 was inoculated in wells A1–F1; Positive control resistant to all the antibiotics was inoculated in wells A2–F2; First tested strain (resistant to CZA, MEV, and IPR) was inoculated in wells A3–F3; Second tested strain (resistant to CZA and FDC) was inoculated in wells A4–F4; and NaCl 0.85% was inoculated in wells A5–F5. Bacterial growth is shown by a colour change of the medium from red to yellow.

: Relebactam purchased from MedChemExpress. Usage Cited in: Antimicrob Agents Chemother. 2023 Jun 15;67(6):e0160322. [Abstract]; Difference between whole cells and isolated PBPs fraction unbound. P. aeruginosa PAO1 cultures (whole cells) and PBP-containing membrane preparations (isolated) were incubated for 15, 30, and 60 min in the presence of relebactam (REL), and afterwards isolated PBPs labeled with 25 μM Boc-FL.

: Relebactam purchased from MedChemExpress. Usage Cited in: Int J Antimicrob Agents. 2022 Nov-Dec;60(5-6):106669. [Abstract]; The MICs of seven β-lactams with relebactam 8 mg/L against M. abscessus.

: Relebactam purchased from MedChemExpress. Usage Cited in: Int J Antimicrob Agents. 2022 Nov-Dec;60(5-6):106669. [Abstract]; The MICs of seven β-lactams with relebactam 8 mg/L against M. massiliense.

: Relebactam purchased from MedChemExpress. Usage Cited in: Antibiotics (Basel). 2021 Nov 3;10(11):1341.; Twenty-four-hour time–kill curves of aztreonam (ATM) and relebactam (REL), alone and in combination, on: C. amalonaticus N18; K. pneumoniae KL 12 SG; K. pneumoniae LC954/14.

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Metallo-β-lactamase (MBL) Serine β-lactamase (SBL)

Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Relebactam combine with Imipenem demonstrates activity against KPC-producing Enterobacteriaceae and multidrug-resistant P. aeruginosa^[1].
Relebactam shows limited inhibition of Class D-producing bacteria and has antipseudomonal activity^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

Molecular Weight

348.38

Formula

C₁₂H₂₀N₄O₆S

CAS No.

1174018-99-5

Appearance

Solid

Color

White to off-white

SMILES

O=S(ON1[C@]2([H])CC[C@@H](C(NC3CCNCC3)=O)[N@@](C2)C1=O)(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

DMSO : 175 mg/mL (502.33 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 50 mg/mL (143.52 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.8704 mL	14.3521 mL	28.7043 mL
5 mM	0.5741 mL	2.8704 mL	5.7409 mL
10 mM	0.2870 mL	1.4352 mL	2.8704 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 25 mg/mL (71.76 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.95%

Select Batch:

Data Sheet (273 KB) SDS (393 KB)

COA (249 KB) HNMR (291 KB) RP-HPLC (185 KB) MS (232 KB)

Handling Instructions (2659 KB)

References

[1]. Lapuebla A, et al. Activity of Imipenem with Relebactam against Gram-Negative Pathogens from New York City. Antimicrob Agents Chemother. 2015 Aug;59(8):5029-31. [Content Brief]

[2]. Bush K. A resurgence of β-lactamase inhibitor combinations effective against multidrug-resistant Gram-negative pathogens. Int J Antimicrob Agents. 2015 Nov;46(5):483-93. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	2.8704 mL	14.3521 mL	28.7043 mL	71.7607 mL
	5 mM	0.5741 mL	2.8704 mL	5.7409 mL	14.3521 mL
	10 mM	0.2870 mL	1.4352 mL	2.8704 mL	7.1761 mL
	15 mM	0.1914 mL	0.9568 mL	1.9136 mL	4.7840 mL
	20 mM	0.1435 mL	0.7176 mL	1.4352 mL	3.5880 mL
	25 mM	0.1148 mL	0.5741 mL	1.1482 mL	2.8704 mL
	30 mM	0.0957 mL	0.4784 mL	0.9568 mL	2.3920 mL
	40 mM	0.0718 mL	0.3588 mL	0.7176 mL	1.7940 mL
	50 mM	0.0574 mL	0.2870 mL	0.5741 mL	1.4352 mL
	60 mM	0.0478 mL	0.2392 mL	0.4784 mL	1.1960 mL
	80 mM	0.0359 mL	0.1794 mL	0.3588 mL	0.8970 mL
	100 mM	0.0287 mL	0.1435 mL	0.2870 mL	0.7176 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Relebactam Related Classifications

Infection

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Relebactam1174018-99-5MK-7655MK7655MK 7655Beta-lactamaseBacterialβ-lactamaseImipenemEnterobacteriaceaeP. aeruginosaβ-lactamasesantibacterialInhibitorinhibitorinhibit

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Relebactam (Synonyms: MK-7655)

Customer Review

Other Forms of Relebactam:

Relebactam Related Antibodies

29 Publications Citing Use of MCE Relebactam

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Beta-lactamase Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

Relebactam Related Antibodies

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

Relebactam Related Classifications

Keywords:

Your Recently Viewed Products:

Customer Review

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SAFETY DATA SHEET (SDS)

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