1. Anti-infection
  2. Bacterial
  3. Relebactam

Relebactam (Synonyms: MK-7655)

Cat. No.: HY-16752 Purity: 98.94%
Handling Instructions

Relebactam is a diazabicyclooctane inhibitor with activity against a wide spectrum of β-lactamases, including class A (extended-spectrum β-lactamases [ESBLs] and KPC) and class C (AmpC) enzymes.

For research use only. We do not sell to patients.

Relebactam Chemical Structure

Relebactam Chemical Structure

CAS No. : 1174018-99-5

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10 mM * 1 mL in Water USD 132 In-stock
Estimated Time of Arrival: December 31
5 mg USD 120 In-stock
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10 mg USD 190 In-stock
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25 mg USD 350 In-stock
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50 mg USD 650 In-stock
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100 mg USD 990 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Relebactam is a diazabicyclooctane inhibitor with activity against a wide spectrum of β-lactamases, including class A (extended-spectrum β-lactamases [ESBLs] and KPC) and class C (AmpC) enzymes. Target: beta-lactamase Imipenem with Relebactam is active against Escherichia coli, Klebsiella pneumoniae, and Enterobacter spp., including K. pneumoniae carbapenemase (KPC)-producing isolates. The combination of Imipenem with Relebactam demonstrated activity against KPC-producing Enterobacteriaceae and multidrug-resistant P. aeruginosa. The imipenem MIC50 and MIC90 values for the ESBL-producing isolates were 0.25 and 0.5 μg/ml, respectively; with the addition of Relebactam, the corresponding values were 0.25 and 0.25 μg/ml. Five isolates harbored blaKPC. For these 5 isolates, the imipenem MICs ranged from 0.5 to >32 μg/ml. With the addition of Relebactam, the MICs decreased to 0.12 to 0.5 μg/ml.[1] Relebactam inhibits most class A and class C β-lactamases, with selected inhibition of class D enzymes by avibactam. β-Lactamase inhibitors (BLIs) have played an important role in combatting β-lactam resistance in Gram-negative bacteria, but their effectiveness has diminished with the evolution of diverse and deleterious varieties of β-lactamases.[2]

Clinical Trial
Molecular Weight

348.38

Formula

C₁₂H₂₀N₄O₆S

CAS No.

1174018-99-5

SMILES

O=S(ON1[[email protected]]2([H])CC[[email protected]@H](C(NC3CCNCC3)=O)[[email protected]@](C2)C1=O)(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 72 mg/mL (206.67 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8704 mL 14.3521 mL 28.7043 mL
5 mM 0.5741 mL 2.8704 mL 5.7409 mL
10 mM 0.2870 mL 1.4352 mL 2.8704 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

RelebactamMK-7655MK7655MK 7655BacterialInhibitorinhibitorinhibit

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