2. Anti-infection
  3. Bacterial Beta-lactamase
  4. Relebactam sodium

Relebactam sodium (MK-7655 sodium) is a potent and selective β-lactamase inhibitor with the activity of delaying the development of bacterial resistance to antibiotics. Relebactam sodium can bind to a variety of β-lactamases, thereby improving the efficacy of β-lactam antibiotics. Relebactam sodium shows good application potential in inhibiting complicated bacterial infections.

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CAS No. : 1502858-91-4

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Relebactam sodium Related Antibodies

Top Publications Citing Use of Products

29 Publications Citing Use of MCE Relebactam sodium

Microbiological Assay
Bio/Physico-chemical Assay

    Relebactam sodium purchased from MedChemExpress. Usage Cited in: Int J Antimicrob Agents. 2024 May 14:107206.  [Abstract]

    The MultiRapid ATB NP test. Column D shows the solution with imipenem–relebactam (IPR, 12/4 mg/L);. Reference strain Escherichia coli ATCC 25922 was inoculated in wells A1–F1; Positive control resistant to all the antibiotics was inoculated in wells A2–F2; First tested strain (resistant to CZA, MEV, and IPR) was inoculated in wells A3–F3; Second tested strain (resistant to CZA and FDC) was inoculated in wells A4–F4; and NaCl 0.85% was inoculated in wells A5–F5. Bacterial growth is shown by a colour change of the medium from red to yellow.

    Relebactam sodium purchased from MedChemExpress. Usage Cited in: Antimicrob Agents Chemother. 2023 Jun 15;67(6):e0160322.  [Abstract]

    Difference between whole cells and isolated PBPs fraction unbound. P. aeruginosa PAO1 cultures (whole cells) and PBP-containing membrane preparations (isolated) were incubated for 15, 30, and 60 min in the presence of relebactam (REL), and afterwards isolated PBPs labeled with 25 μM Boc-FL.

    Relebactam sodium purchased from MedChemExpress. Usage Cited in: Int J Antimicrob Agents. 2022 Nov-Dec;60(5-6):106669.  [Abstract]

    The MICs of seven β-lactams with relebactam 8 mg/L against M. abscessus.

    Relebactam sodium purchased from MedChemExpress. Usage Cited in: Int J Antimicrob Agents. 2022 Nov-Dec;60(5-6):106669.  [Abstract]

    The MICs of seven β-lactams with relebactam 8 mg/L against M. massiliense.

    Relebactam sodium purchased from MedChemExpress. Usage Cited in: Antibiotics (Basel). 2021 Nov 3;10(11):1341.

    Twenty-four-hour time–kill curves of aztreonam (ATM) and relebactam (REL), alone and in combination, on: C. amalonaticus N18; K. pneumoniae KL 12 SG; K. pneumoniae LC954/14.

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    Description

    Relebactam sodium (MK-7655 sodium) is a potent and selective β-lactamase inhibitor with the activity of delaying the development of bacterial resistance to antibiotics. Relebactam sodium can bind to a variety of β-lactamases, thereby improving the efficacy of β-lactam antibiotics. Relebactam sodium shows good application potential in inhibiting complicated bacterial infections[1].

    Molecular Weight

    370.36

    Formula

    C12H19N4NaO6S
    CAS No.
    SMILES

    O=S(ON1[C@]2([H])CC[C@@H](C(NC3CCNCC3)=O)[N@@](C2)C1=O)(O[Na])=O
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
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    Relebactam sodium Related Classifications

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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Relebactam1502858-91-4MK-7655MK7655MK 7655BacterialBeta-lactamaseβ-lactamaseImipenemEnterobacteriaceaeP. aeruginosaβ-lactamasesantibacterialInhibitorinhibitorinhibit

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