1. Neuronal Signaling
  2. Beta-secretase Cholinesterase (ChE)
  3. Tenuifolin

Tenuifolin 

Cat. No.: HY-N0702 Purity: ≥99.0%
COA Handling Instructions

Tenuifolin is effective and has a protective action. Tenuifolin inhibits β-secretase decreases Aβ protein secretion, suppresses Aβ25-35 secretion, and subsequently caspase-3 and caspase-9 become active. Tenuifolin's ability to lower AChE activity, increase at the same time, increase the ability of the upper glands, and improve the ability to read and remember. Research on tenuifolin's potential for use in urinary disease (AD).

For research use only. We do not sell to patients.

Tenuifolin Chemical Structure

Tenuifolin Chemical Structure

CAS No. : 20183-47-5

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1 mg USD 23 In-stock
5 mg USD 50 In-stock
10 mg USD 90 In-stock
20 mg USD 150 In-stock
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Based on 1 publication(s) in Google Scholar

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  • References

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Description

Tenuifolin is effective and has a protective action. Tenuifolin inhibits β-secretase decreases Aβ protein secretion, suppresses Aβ25-35 secretion, and subsequently caspase-3 and caspase-9 become active. Tenuifolin's ability to lower AChE activity, increase at the same time, increase the ability of the upper glands, and improve the ability to read and remember. Research on tenuifolin's potential for use in urinary disease (AD).

IC50 & Target

AChE

 

In Vitro

Tenuifolin (50 μM; 24 h) protects SH-SY5Y cells against Aβ25-35 (20 μM)-induced apoptosis, and decreased the mRNA level of caspase-3 and -9[2].
Tenuifolin (50 μM, 100 μM; 24 h) inhibits Aβ25-35 (20 μM)-induced the loss of mitochondria-membrane potential in SH-SY5Y cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Tenuifolin (20-80 mg/kg; po; single dose) induces beneficial effects on learning and memory, prevents loss and apoptosis of neurons in APP/PS1 mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

680.82

Formula

C36H56O12

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC[C@@]1(CC[C@]2(C(O)=O)[C@@]3([H])CC(C)(C)CC2)C3=CC[C@@]4([H])[C@]1(CC[C@]5([H])[C@@]4(C[C@H](O)[C@H](O[C@]([C@@H]([C@@H](O)[C@@H]6O)O)([H])O[C@@H]6CO)[C@@]5(C)C(O)=O)C)C

Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (146.88 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4688 mL 7.3441 mL 14.6882 mL
5 mM 0.2938 mL 1.4688 mL 2.9376 mL
10 mM 0.1469 mL 0.7344 mL 1.4688 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (3.67 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (3.67 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (3.67 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation

Purity: ≥99.0%

References
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Tenuifolin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Tenuifolin
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