1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. GABA Receptor
  3. 3,4,5-Trimethoxycinnamic acid

3,4,5-Trimethoxycinnamic acid 

Cat. No.: HY-W012123 Purity: 99.22%
Handling Instructions

3,4,5-Trimethoxycinnamic acid is a phenylpropanoid isolated from the roots of Polygala tenuifolia WILLD, with anti-stress effect, prolonging the sleeping time in animals. 3,4,5-Trimethoxycinnamic acid increases expression of GAD65 and γ-subunit of GABAA receptor, but shows no effect on the amounts of α-, β-subunits.

For research use only. We do not sell to patients.

3,4,5-Trimethoxycinnamic acid Chemical Structure

3,4,5-Trimethoxycinnamic acid Chemical Structure

CAS No. : 90-50-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
100 mg USD 50 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
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Description

3,4,5-Trimethoxycinnamic acid is a phenylpropanoid isolated from the roots of Polygala tenuifolia WILLD, with anti-stress effect, prolonging the sleeping time in animals[1][2]. 3,4,5-Trimethoxycinnamic acid increases expression of GAD65 and γ-subunit of GABAA receptor, but shows no effect on the amounts of α-, β-subunits[2].

IC50 & Target

γ-subunit of GABAA receptor[2]

In Vitro

3,4,5-Trimethoxycinnamic acid (10 μg/ml) increases expression of GAD65 and γ-subunit of GABAA receptor, but shows no effect on the amounts of α-, β-subunits[2].

In Vivo

3,4,5-Trimethoxycinnamic acid (25-100 mg/kg, i.p.) exhibits sedative effect, and prolongs the sleeping time in rats[1].
3,4,5-Trimethoxycinnamic acid (10 mg/kg, p.o.) significantly decreases locomotor activity in mice[2].

Molecular Weight

238.24

Formula

C₁₂H₁₄O₅

CAS No.

90-50-6

SMILES

COC1=C(OC)C(OC)=CC(/C=C/C(O)=O)=C1

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: 99.22%

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Product Name:
3,4,5-Trimethoxycinnamic acid
Cat. No.:
HY-W012123
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