90-50-6
90-50-6
Chemical Structure
3,4,5-Trimethoxycinnamic acid
- CAS No.: 90-50-6
- Formula:C12H14O5
- Molecular Weight:238.24
IUPAC Name: (E)-3-(3,4,5-trimethoxyphenyl)acrylic acid
InChIKey: YTFVRYKNXDADBI-SNAWJCMRSA-N
SMILES: COC1=C(OC)C(OC)=CC(/C=C/C(O)=O)=C1
Biological Activity: 3,4,5-Trimethoxycinnamic acid is a phenylpropanoid isolated from the roots of Polygala tenuifolia WILLD, with anti-stress effect, prolonging the sleeping time in animals[1][2]. 3,4,5-Trimethoxycinnamic acid increases expression of GAD65 and γ-subunit of GABAA receptor, but shows no effect on the amounts of α-, β-subunits[2].
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3,4,5-Trimethoxycinnamic acid | 99.96% | 3,4,5-Trimethoxycinnamic acid is a phenylpropanoid isolated from the roots of Polygala tenuifolia WILLD, with anti-stress effect, prolonging the sleeping time in animals. 3,4,5-Trimethoxycinnamic acid increases expression of GAD65 and γ-subunit of GABAA receptor, but shows no effect on the amounts of α-, β-subunits. | ||||||||||||||||||||
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3,4,5-Trimethoxycinnamic acid (Standard) | ≥98% | 3,4,5-Trimethoxycinnamic acid is a phenylpropanoid isolated from the roots of Polygala tenuifolia WILLD, with anti-stress effect, prolonging the sleeping time in animals. 3,4,5-Trimethoxycinnamic acid increases expression of GAD65 and γ-subunit of GABAA receptor, but shows no effect on the amounts of α-, β-subunits. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 1.00
HY-W050162(E)-3,4,5-Trimethoxycinnamic acid -
Similarity Score 0.90
HY-B1255Cintriamide -
Similarity Score 0.88
HY-N3289Methyl 3,4,5-trimethoxycinnamate -
Similarity Score 0.88
HY-N3289A(E)-Methyl 3,4,5-trimethoxycinnamate -
Similarity Score 0.87
HY-W009732Acis-Sinapinic acid -
Similarity Score 0.87
HY-W009732RSinapinic acid (Standard) -
Similarity Score 0.85
HY-N1767trans-3,4,5-Trimethoxycinnamyl alcohol -
Similarity Score 0.83
HY-N3265Methyl sinapate -
Similarity Score 0.83
HY-N3265A(E)-Methyl sinapate -
Explore the MedChemAI to find more analogs
References
- [1]. Kawashima K, et al. Anti-stress effects of 3,4,5-trimethoxycinnamic acid, an active constituent of roots of Polygala tenuifolia (Onji). Biol Pharm Bull. 2004 Aug;27(8):1317-9. [Content Brief]
- [2]. Lee CI, et al. 3,4,5-Trimethoxycinnamic acid (TMCA), one of the constituents of Polygalae Radix enhances pentobarbital-induced sleeping behaviors via GABAAergic systems in mice. Arch Pharm Res. 2013 Oct;36(10):1244-51. [Content Brief]
