2. Cell Cycle/DNA Damage Anti-infection
  3. Nucleoside Antimetabolite/Analog Influenza Virus DNA/RNA Synthesis
  4. Triazavirin

Triazavirin 

Cat. No.: HY-19743 Purity: 99.12%
COA Handling Instructions

Triazavirin is a nucleoside analogue of nucleic acid and an antiviral agent. Triazavirin works by inhibiting the synthesis of viral RNA and DNA and replication of genomic fragments. Triazavirin is also an effective protective agent on the transmission stage of influenza.

For research use only. We do not sell to patients.

Triazavirin Chemical Structure

Triazavirin Chemical Structure

CAS No. : 928659-17-0

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10 mg USD 110 In-stock
50 mg USD 310 In-stock
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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Triazavirin Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Triazavirin is a nucleoside analogue of nucleic acid and an antiviral agent. Triazavirin works by inhibiting the synthesis of viral RNA and DNA and replication of genomic fragments. Triazavirin is also an effective protective agent on the transmission stage of influenza[1].

IC50 & Target

Nucleoside analogue; Influenza virus[1]
In Vitro

The efficacy of Triazavirin against the tick-borne encephalitis virus is estimated in the sensitive cell culture. In a concentration of 128 mcg/mL Triazavirin is shown active in inhibition of the tick-borne encephalitis virus reproduction (strain Sofiin) by accumulation in the SKEV cell culture[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Triazavirin Related Antibodies
In Vivo

The therapeutic efficacy Triazavirin against experimental Forest-Spring encephalitis on albino mice is studied. The results shows that in high doses (200-400 mg/kg) Triazavirin moderately protects the infected animals. A significant increase of the animal lifespan in the test groups (from 4.1 to 4.8 days) and a statistically valid decrease of the virus accumulation in the target organ are observed[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

286.20

Appearance

Solid

Formula

C5H7N6NaO5S
CAS No.
SMILES

O=C1N([N-]C(SC)=N2)C2=NN=C1[N+]([O-])=O.[H]O[H].[H]O[H].[Na+]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (436.76 mM; Need ultrasonic)

H2O : 50 mg/mL (174.70 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4941 mL 17.4703 mL 34.9406 mL
5 mM 0.6988 mL 3.4941 mL 6.9881 mL
10 mM 0.3494 mL 1.7470 mL 3.4941 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (7.27 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (7.27 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.12%

COA (247 KB) HNMR (230 KB) LCMS (259 KB)

Handling Instructions (2659 KB)
References
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Triazavirin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Triazavirin928659-17-0Nucleoside Antimetabolite/AnalogInfluenza VirusDNA/RNA SynthesisTick-bornencephalitisinfluenzatransmissionnucleosideantiviralreplicationDNARNAInhibitorinhibitorinhibit

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