[Investigation of Therapeutic Efficacy of Triazavirin Against Experimental Forest-Spring Encephalitis on Albino Mice]

  • Antibiot Khimioter. 2015;60(7-8):11-3.
S Ya Loginova ,  S V Borisevich ,  V L Rusinov ,  E N Ulomsky ,  V N Charushin ,  O N Chupakhin ,  P V Sorokin
PMID: 26863736
Abstract

The comparative study of the therapeutic efficacy of Triazavirin against experimental Forest-Spring encephalitis on albino mice vs. the active drug Ribavirin® showed that in high doses (200-400 mg/kg) Triazavirin moderately protected the infected Animals. A significant increase of the animal lifespan in the test groups (from 4.1 to 4.8 days) and a statistically (p ≤ 0.05) valid decrease of the virus accumulation in the target organ (the brain) were observed.

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