G-CSFR/CD114 Protein, Mouse (HEK293, His)

G-CSFR/CD114 Protein, functioning as the receptor for granulocyte colony-stimulating factor (CSF3), plays a pivotal role in granulocyte development and function. As a homodimer, it binds two CSF3 molecules, transducing signals. G-CSFR/CD114's interaction with CEACAM1 down-regulates the CSF3R-STAT3 pathway, recruiting PTPN6 for dephosphorylation, revealing regulatory roles in modulating granulocyte colony-stimulating factor responses. These interactions emphasize G-CSFR/CD114's intricate regulatory involvement in immune responses and hematopoiesis. G-CSFR/CD114 Protein, Mouse (HEK293, His) is the recombinant mouse-derived G-CSFR/CD114 protein, expressed by HEK293, with C-His labeled tag. The total length of G-CSFR/CD114 Protein, Mouse (HEK293, His) is 601 a.a., with molecular weight of 90-110 kDa.

G-CSFR/CD114 Protein acts as the receptor for granulocyte colony-stimulating factor (CSF3) and may additionally play a role in certain adhesion or recognition events at the cell surface. Existing as a homodimer, the receptor binds two CSF3 molecules, facilitating the transduction of signals related to granulocyte development and function. Moreover, G-CSFR/CD114 interacts with CEACAM1, leading to the down-regulation of the CSF3R-STAT3 pathway. This process involves the recruitment of PTPN6, which subsequently dephosphorylates CSF3R, revealing a regulatory aspect of G-CSFR/CD114 in modulating signaling pathways associated with granulocyte colony-stimulating factor responses. These interactions highlight the intricate regulatory roles of G-CSFR/CD114 in cellular processes related to immune responses and hematopoiesis.

Mouse

HEK293

C-His

P40223 (C26-D626)

12986  [NCBI]

90-110 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.