Csf3r - colony stimulating factor 3 receptor (granulocyte) Gene

Also Known as Cd114; Csfgr; G-CSFR; G-CSF-R

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12986

Summary

Enables granulocyte colony-stimulating factor binding activity. Acts upstream of or within neutrophil chemotaxis and regulation of myeloid cell differentiation. Predicted to be located in endocytic vesicle membrane and plasma membrane. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including bone marrow; dorsal aorta; early conceptus; gut; and reproductive system. Used to study hereditary neutrophilia. Human ortholog(s) of this gene implicated in hematologic Cancer (multiple) and severe congenital neutropenia (multiple). Orthologous to human CSF3R (colony stimulating factor 3 receptor). [provided by Alliance of Genome Resources, Apr 2022]

Csf3r Products (2)

mRNA Protein Name
NM_001252651.1 NP_001239580.1 granulocyte colony-stimulating factor receptor isoform 2 precursor
NM_007782.3 NP_031808.2 granulocyte colony-stimulating factor receptor isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables granulocyte colony-stimulating factor binding IPI
IPI: Inferred from physical interaction
2158861 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
21029969 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within neutrophil chemotaxis IMP
IMP: Inferred from mutant phenotype
10485650 MGI
acts upstream of or within regulation of myeloid cell differentiation IGI
IGI: Inferred from genetic interaction
23136256 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

granulocyte colony-stimulating factor receptor

  • G-CSF receptor

Recombinant Csf3r Proteins

Cat. No. Product Name Accession Purity
HY-P700725 G-CSFR/CD114 Protein, Mouse (HEK293, His) P40223 (C26-D626) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03235 CSF3R Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17380 Csf3r Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23834 Csf3r Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Csf3r NCBI NCBI:1441