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  3. Megestrol acetate

Megestrol acetate 

Cat. No.: HY-13676 Purity: 99.81%
Handling Instructions

Megestrol acetate is a synthetic progesteronal agent with an IC50 of 260 μM for the inhibition of HegG2.

For research use only. We do not sell to patients.

Megestrol acetate Chemical Structure

Megestrol acetate Chemical Structure

CAS No. : 595-33-5

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1  mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
500 mg USD 50 In-stock
Estimated Time of Arrival: December 31
1 g USD 66 In-stock
Estimated Time of Arrival: December 31
5 g USD 202 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Megestrol acetate is a synthetic progesteronal agent with an IC50 of 260 μM for the inhibition of HegG2. Target: Progesterone Receptor Megestrol acetate, also known as 17α-acetoxy-6-dehydro-6-methylprogesterone, and sometimes abbreviated as MGA or MA, is a steroidal progestin and progesterone derivative (specifically, a 17-hydroxylated progesterone) with predominantly progestational and antigonadotropic effects. Megestrol acetate is a good candidate for muscle wasting treatment and future studies addressed at the interaction between the drug and protein turnover in human skeletal muscle should be performed.

Molecular Weight

384.51

Formula

C₂₄H₃₂O₄

CAS No.

595-33-5

SMILES

CC([[email protected]@]1(OC(C)=O)CC[[email protected]@]2([H])[[email protected]]3([H])C=C(C)C4=CC(CC[[email protected]]4(C)[[email protected]@]3([H])CC[[email protected]]12C)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 20 mg/mL (52.01 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6007 mL 13.0036 mL 26.0071 mL
5 mM 0.5201 mL 2.6007 mL 5.2014 mL
10 mM 0.2601 mL 1.3004 mL 2.6007 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2 mg/mL (5.20 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2 mg/mL (5.20 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2 mg/mL (5.20 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

MegestrolProgesterone ReceptorAutophagyHIVNR3C3Human immunodeficiency virusInhibitorinhibitorinhibit

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Megestrol acetate
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HY-13676
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