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  3. Megestrol acetate

Megestrol acetate 

Cat. No.: HY-13676 Purity: 99.81%
Handling Instructions

Megestrol acetate is a synthetic and orally active progesteronal agent. Megestrol acetate is effective as an appetite stimulant for wasting syndromes such as cachexia. Megestrol acetate decreases nuclear and cytosol androgen receptors human BPH tissue. Megestrol acetate has the potential for HIV study and downregulates autophagic catabolic pathway.

For research use only. We do not sell to patients.

Megestrol acetate Chemical Structure

Megestrol acetate Chemical Structure

CAS No. : 595-33-5

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10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
500 mg USD 50 In-stock
Estimated Time of Arrival: December 31
1 g USD 66 In-stock
Estimated Time of Arrival: December 31
5 g USD 202 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Megestrol acetate is a synthetic and orally active progesteronal agent. Megestrol acetate is effective as an appetite stimulant for wasting syndromes such as cachexia. Megestrol acetate decreases nuclear and cytosol androgen receptors human BPH tissue. Megestrol acetate has the potential for HIV study and downregulates autophagic catabolic pathway[1][2][3][4][5].

In Vitro

Megestrol acetate alone results in an ICKY of 48.7 p,M in the MCF7/ADR cell line[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Megestrol acetate (100 or 300 mg/kg, Subcutaneously daily over a 7-day period) is able to reduce the weight loss produced by both TNF and by the MAC16 tumour[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Pure strain female NMRI mice (age 6 to 8 weeks)[1].
Dosage: 100 or 300 mg/kg (50 mg megestrol acetate was suspended in 3 ml of pure corn oil).
Administration: Subcutaneously daily over a 7-day period.
Result: Produced a highly significant reversal of the TNF-induced decrease in body weight, accompanied by a significant increase in both food and water intake.
Caused an increase in body weight over a 24-hour period to female NMRI mice.
No effect on blood glucose levels in saline controls, concurrent administration of megestrol acetate with TNF caused a significant increase in blood glucose compared with administration of TNF alone.
Caused a dose-related reduction in the loss of host body weight in animals bearing the MAC16 tumour.
Clinical Trial
Molecular Weight

384.51

Formula

C₂₄H₃₂O₄

CAS No.

595-33-5

SMILES

CC([[email protected]@]1(OC(C)=O)CC[[email protected]@]2([H])[[email protected]]3([H])C=C(C)C4=CC(CC[[email protected]]4(C)[[email protected]@]3([H])CC[[email protected]]12C)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 20 mg/mL (52.01 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6007 mL 13.0036 mL 26.0071 mL
5 mM 0.5201 mL 2.6007 mL 5.2014 mL
10 mM 0.2601 mL 1.3004 mL 2.6007 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2 mg/mL (5.20 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2 mg/mL (5.20 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2 mg/mL (5.20 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

MegestrolProgesterone ReceptorAutophagyHIVNR3C3Human immunodeficiency virusAnorexiacachexiasyndromeACSBPHAIDsInhibitorinhibitorinhibit

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Product Name:
Megestrol acetate
Cat. No.:
HY-13676
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