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  3. Diethylstilbestrol

Diethylstilbestrol (Synonyms: Stilbestrol; DES)

Cat. No.: HY-14598 Purity: 98.54%
Handling Instructions

Diethylstilbestrol, a synthetic nonsteroidal estrogen used in the treatment of menopausal and postmenopausal disorders.

For research use only. We do not sell to patients.

Diethylstilbestrol Chemical Structure

Diethylstilbestrol Chemical Structure

CAS No. : 56-53-1

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10 mM * 1  mL in DMSO USD 66 In-stock
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200 mg USD 60 In-stock
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1 g USD 72 In-stock
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5 g USD 108 In-stock
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Description

Diethylstilbestrol, a synthetic nonsteroidal estrogen used in the treatment of menopausal and postmenopausal disorders. Target: Estrogen Receptor/ERR Diethylstilbestrol (DES), a synthetic estrogen that was used in pregnancy, is a prototype endocrine-disrupting chemical. Although prenatal exposure to DES is known to increase risks of vaginal/cervical adenocarcinoma and adverse reproductive outcomes in women, and urogenital anomalies in men, data on nonreproductive medical conditions are lacking. Comparing persons exposed prenatally to DES with those who were not exposed, the hazard ratios were 1.21 (95% confidence interval = 0.96-1.54) for diabetes, 1.27 (1.00-1.62) for all cardiovascular disease, 1.18 (0.88-1.59) for coronary artery disease, 1.28 (0.88-1.86) for myocardial infarction, 1.12 (1.02-1.22) for high cholesterol, 1.14 (1.02-1.28) for hypertension, 1.24 (0.99-1.54) for osteoporosis, and 1.30 (0.95-1.79) for fractures. The associations did not differ by dose and timing of DES exposure, nor, in the women, by the presence or absence of vaginal epithelial changes (a marker of DES host susceptibility) [1]. The role of prenatal exposure to DES as an environmental risk factor for psychiatric disorders requires more evidence before any conclusions can be drawn [2].

Clinical Trial
Molecular Weight

268.35

Formula

C₁₈H₂₀O₂

CAS No.

56-53-1

SMILES

OC1=CC=C(/C(CC)=C(CC)/C2=CC=C(O)C=C2)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (186.32 mM; Need ultrasonic)

Methanol : ≥ 33.33 mg/mL (124.20 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7265 mL 18.6324 mL 37.2648 mL
5 mM 0.7453 mL 3.7265 mL 7.4530 mL
10 mM 0.3726 mL 1.8632 mL 3.7265 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (9.32 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (9.32 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 98.54%

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Keywords:

DiethylstilbestrolStilbestrolDESEstrogen Receptor/ERRInhibitorinhibitorinhibit

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Product name:
Diethylstilbestrol
Cat. No.:
HY-14598
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