56-53-1
56-53-1
Chemical Structure
Diethylstilbestrol
- CAS No.: 56-53-1
- Formula:C18H20O2
- Molecular Weight:268.35
IUPAC Name: (E)-4,4'-(hex-3-ene-3,4-diyl)diphenol
InChIKey: RGLYKWWBQGJZGM-ISLYRVAYSA-N
SMILES: OC1=CC=C(/C(CC)=C(CC)/C2=CC=C(O)C=C2)C=C1
Biological Activity: Diethylstilbestrol is a non-steroidal female hormone that has oral activity and can act on menopausal and postmenopausal disorders. Diethylstilbestrol can induce DNA oxidation and Apoptosis of spermatogonial stem cells. Diethylstilbestrol can induce thymocyte Autophagy Diethylstilbestrol is a 11β-hydroxysteroid dehydrogenase 2 (HSD11B2) inhibitor.[1][2][3][4][5][6][7][8].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Diethylstilbestrol | 99.62% | Diethylstilbestrol is a non-steroidal female hormone that has oral activity and can act on menopausal and postmenopausal disorders. Diethylstilbestrol can induce DNA oxidation and Apoptosis of spermatogonial stem cells. Diethylstilbestrol can induce thymocyte Autophagy Diethylstilbestrol is a 11β-hydroxysteroid dehydrogenase 2 (HSD11B2) inhibitor.. | ||||||||||||||||||||
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Diethylstilbestrol (Standard) | 99.15% | Diethylstilbestrol (Standard) is the analytical standard of Diethylstilbestrol. This product is intended for research and analytical applications. Diethylstilbestrol (Stilbestrol) is a non-steroidal female hormone that has oral activity and can act on menopausal and postmenopausal disorders. Diethylstilbestrol can induce DNA oxidation and Apoptosis of spermatogonial stem cells. Diethylstilbestrol can induce thymocyte Autophagy Diethylstilbestrol is a 11β-hydroxysteroid dehydrogenase 2 (HSD11B2) inhibitor.. | ||||||||||||||||||||
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Diethylstilbestrol-d3 | Diethylstilbestrol-d3 is deuterium labeled Diethylstilbestrol. | |||||||||||||||||||||
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Diethylstilbestrol-d4 | Diethylstilbestrol-d4 is the deuterium labeled Diethylstilbestrol (HY-14598). Diethylstilbestrol is a non-steroidal female hormone that has oral activity and can act on menopausal and postmenopausal disorders. Diethylstilbestrol can induce DNA oxidation and?Apoptosis?of spermatogonial stem cells. Diethylstilbestrol can induce thymocyte?Autophagy?Diethylstilbestrol is a?11β-hydroxysteroid dehydrogenase 2 (HSD11B2)?inhibitor. | |||||||||||||||||||||
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Diethylstilbestrol-d8 | 99% | Diethylstilbestrol-d8 is the deuterium labeled Diethylstilbestrol. Diethylstilbestrol, a synthetic nonsteroidal estrogen used in the treatment of menopausal and postmenopausal disorders. | ||||||||||||||||||||
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References
- [1]. Troisi, R., et al., Medical conditions among adult offspring prenatally exposed to diethylstilbestrol. Epidemiology, 2013. 24(3): p. 430-8. [Content Brief]
- [2]. Kebir, O. and M.O. Krebs, Diethylstilbestrol and risk of psychiatric disorders: a critical review and new insights. World J Biol Psychiatry, 2012. 13(2): p. 84-95. [Content Brief]
- [3]. Li Y, et al. Diethylstilbestrol (DES)-stimulated hormonal toxicity is mediated by ERα alteration of target gene methylation patterns and epigenetic modifiers (DNMT3A, MBD2, and HDAC2) in the mouse seminal vesicle. Environ Health Perspect. 2014 Mar;122(3):262-8. [Content Brief]
- [4]. Haeno S, et al. Diethylstilbestrol decreased adrenal cholesterol and corticosterone in rats. J Endocrinol. 2014 Apr 22;221(2):261-72. [Content Brief]
- [5]. Zou QX, et al. Diethylstilbestrol activates CatSper and disturbs progesterone actions in human spermatozoa. Hum Reprod. 2017 Feb;32(2):290-298. [Content Brief]
- [6]. Singh NP, et al. Diethylstilbestrol (DES) induces autophagy in thymocytes by regulating Beclin-1 expression through epigenetic modulation. Toxicology. 2018 Dec 1;410:49-58. [Content Brief]
- [7]. Habas K, et al. Diethylstilbestrol induces oxidative DNA damage, resulting in apoptosis of spermatogonial stem cells in vitro. Toxicology. 2017 May 1;382:117-121. [Content Brief]
- [8]. Wang Y, et al. Diethylstilbestrol inhibits human and rat 11β-hydroxysteroid dehydrogenase 2. Endocr Connect. 2019 Jul;8(7):1061-1069. [Content Brief]
