56-53-1
56-53-1
Chemical Structure
Diethylstilbestrol
- CAS. Nr.: 56-53-1
- Formula:C18H20O2
- Molecular Weight:268.35
IUPAC Name: (E)-4,4'-(hex-3-ene-3,4-diyl)diphenol
InChIKey: RGLYKWWBQGJZGM-ISLYRVAYSA-N
SMILES: OC1=CC=C(/C(CC)=C(CC)/C2=CC=C(O)C=C2)C=C1
Biological Activity: Diethylstilbestrol is a non-steroidal female hormone that has oral activity and can act on menopausal and postmenopausal disorders. Diethylstilbestrol can induce DNA oxidation and Apoptosis of spermatogonial stem cells. Diethylstilbestrol can induce thymocyte Autophagy Diethylstilbestrol is a 11β-hydroxysteroid dehydrogenase 2 (HSD11B2) inhibitor.[1][2][3][4][5][6][7][8].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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Diethylstilbestrol | 99.62% | Diethylstilbestrol is a non-steroidal female hormone that has oral activity and can act on menopausal and postmenopausal disorders. Diethylstilbestrol can induce DNA oxidation and Apoptosis of spermatogonial stem cells. Diethylstilbestrol can induce thymocyte Autophagy Diethylstilbestrol is a 11β-hydroxysteroid dehydrogenase 2 (HSD11B2) inhibitor.. | ||||||||||||||||||||
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Diethylstilbestrol (Standard) | 99.15% | Diethylstilbestrol (Standard) is the analytical standard of Diethylstilbestrol. This product is intended for research and analytical applications. Diethylstilbestrol (Stilbestrol) is a non-steroidal female hormone that has oral activity and can act on menopausal and postmenopausal disorders. Diethylstilbestrol can induce DNA oxidation and Apoptosis of spermatogonial stem cells. Diethylstilbestrol can induce thymocyte Autophagy Diethylstilbestrol is a 11β-hydroxysteroid dehydrogenase 2 (HSD11B2) inhibitor.. | ||||||||||||||||||||
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Diethylstilbestrol-d3 | Diethylstilbestrol-d3 is deuterium labeled Diethylstilbestrol. | |||||||||||||||||||||
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Diethylstilbestrol-d4 | Diethylstilbestrol-d4 is the deuterium labeled Diethylstilbestrol (HY-14598). Diethylstilbestrol is a non-steroidal female hormone that has oral activity and can act on menopausal and postmenopausal disorders. Diethylstilbestrol can induce DNA oxidation and?Apoptosis?of spermatogonial stem cells. Diethylstilbestrol can induce thymocyte?Autophagy?Diethylstilbestrol is a?11β-hydroxysteroid dehydrogenase 2 (HSD11B2)?inhibitor. | |||||||||||||||||||||
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Diethylstilbestrol-d8 | 99.74% | Diethylstilbestrol-d8 is the deuterium labeled Diethylstilbestrol. Diethylstilbestrol, a synthetic nonsteroidal estrogen used in the treatment of menopausal and postmenopausal disorders. | ||||||||||||||||||||
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Dimestrol | Dimestrol (Diethylstilbestrol dimethyl ether) is a precursor of Diethylstilbestrol (HY-14598). | |||||||||||||||||||||
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Z,Z-Dienestrol-d6 | 97.33% | Z,Z-Dienestrol-d6 is the deuterium labeled Z,Z-Dienestrol. | ||||||||||||||||||||
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Resveratrol-d4 | 99.36% | Resveratrol-d4 is the deuterium labeled Resveratrol. Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator. Resveratrol is a potent pregnane X receptor (PXR) inhibitor. Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model. Resveratrol increases production of NO in endothelial cells. | ||||||||||||||||||||
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Bisphenol A-d8 | 99.26% | Bisphenol A-d8 is the deuterium labeled Bisphenol A. Bisphenol A is a phenolic, organic synthetic compound widely used in the production of polycarbonate plastics and epoxy resins. Bisphenol A is a reproductive, developmental, and systemic toxicant, often classified as an endocrine-disrupting compound (EDC). Bisphenol A is associated with many diseases, including cardiovascular diseases, respiratory diseases, diabetes, kidney diseases, obesity, and reproductivedisorders. | ||||||||||||||||||||
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Bisphenol A-d4 | Bisphenol A-d4 is the deuterium labeled Bisphenol A. Bisphenol A is a phenolic, organic synthetic compound widely used in the production of polycarbonate plastics and epoxy resins. Bisphenol A is a reproductive, developmental, and systemic toxicant, often classified as an endocrine-disrupting compound (EDC). Bisphenol A is associated with many diseases, including cardiovascular diseases, respiratory diseases, diabetes, kidney diseases, obesity, and reproductivedisorders. | |||||||||||||||||||||
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Bisphenol A-d4-1 | 99.53% | Bisphenol A-d4-1 is the deuterium labeled Bisphenol A. Bisphenol A is a phenolic, organic synthetic compound widely used in the production of polycarbonate plastics and epoxy resins. Bisphenol A is a reproductive, developmental, and systemic toxicant, often classified as an endocrine-disrupting compound (EDC). Bisphenol A is associated with many diseases, including cardiovascular diseases, respiratory diseases, diabetes, kidney diseases, obesity, and reproductivedisorders. | ||||||||||||||||||||
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ER ligand-15 | ||||||||||||||||||||||
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Dienestrol | 98.04% | Dienestrol is an orally active nonsteroidal estrogen. Dienestrol prevents the formation of implantation swellings in the uterus by inhibiting ovum discharge. | ||||||||||||||||||||
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Dienestrol-d2 | Dienestrol-d2 is a deuterium labeled Dienestrol (HY-B1403). Dienestrol is an orally active nonsteroidal estrogen. Dienestrol prevents the formation of implantation swellings in the uterus by inhibiting ovum discharge. | |||||||||||||||||||||
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Hexestrol | 99.79% | Hexestrol is a nonsteroidal synthetic estrogen, with a Ki of 0.06 and 0.06 nM for estrogen receptor alpha (ERα) and ERβ. Hexestrol can be used for the research of the diseases caused by estrogen deficiencym, and it also can increase the weight of cattle. | ||||||||||||||||||||
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Bisphenol B | 99.34% | Bisphenol B is a close structural analog of Bisphenol A (BPA) (HY-18260). Bisphenol B is a potent, orally active endocrine disruptor (ED). Bisphenol B binds to G protein-coupled estrogen receptor (GPER) (IC50 = 3.3 μM) with higher affinity and agonistic activity than BPA. Bisphenol B promotes GPER mediated cell migration. Bisphenol B exerts estrogenic effects via GPER pathway at nanomolar concentration. Bisphenol B is used in the manufacture of polycarbonate resin with ED properties. | ||||||||||||||||||||
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(Rac)-Hexestrol | (Rac)-Hexestrol is the racemic form of Hexestrol (HY-B1662). Hexestrol is a synthetic non-steroidal estrogen. (Rac)-Hexestrol usually appears in deuterated form and is used as an internal standard for precise quantitative analysis in analytical chemistry. | |||||||||||||||||||||
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Isodienestrol | Isodienestrol, a Diethylstilbestrol (HY-14598) derivative, is a Microtubule inhibitor. Isodienestrol can be used for cancers research | |||||||||||||||||||||
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(±)-Enterodiol-d6 | (±)-Enterodiol-d6 is the deuterium labeled (±)-Enterodiol (HY-108695B). (±)-Enterodiol is the racemate of Enterodiol (HY-108695). Enterodiol is transformed by human intestinal bacteria from lignans contained in various whole-grain cereals, nuts, legumes, flaxseed, and vegetables. Enterodiol has an apoptotic effect in colorectal cancer (CRC) cells. Enterodiol has anti-cancer activities. | |||||||||||||||||||||
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cis-3,4-Di-p-anisyl-3-hexene-d6 | cis-3,4-Di-p-anisyl-3-hexene-d6 is the deuterium labeled D-Fructose (HY-N7092). D-Fructose (D(-)-Fructose) is a monosaccharide found in honey, fruits, and?other?plants. Two D-Fructose molecules can combine to form a disaccharide, sucrose. | |||||||||||||||||||||
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References
- [1]. Troisi, R., et al., Medical conditions among adult offspring prenatally exposed to diethylstilbestrol. Epidemiology, 2013. 24(3): p. 430-8. [Content Brief]
- [2]. Kebir, O. and M.O. Krebs, Diethylstilbestrol and risk of psychiatric disorders: a critical review and new insights. World J Biol Psychiatry, 2012. 13(2): p. 84-95. [Content Brief]
- [3]. Li Y, et al. Diethylstilbestrol (DES)-stimulated hormonal toxicity is mediated by ERα alteration of target gene methylation patterns and epigenetic modifiers (DNMT3A, MBD2, and HDAC2) in the mouse seminal vesicle. Environ Health Perspect. 2014 Mar;122(3):262-8. [Content Brief]
- [4]. Haeno S, et al. Diethylstilbestrol decreased adrenal cholesterol and corticosterone in rats. J Endocrinol. 2014 Apr 22;221(2):261-72. [Content Brief]
- [5]. Zou QX, et al. Diethylstilbestrol activates CatSper and disturbs progesterone actions in human spermatozoa. Hum Reprod. 2017 Feb;32(2):290-298. [Content Brief]
- [6]. Singh NP, et al. Diethylstilbestrol (DES) induces autophagy in thymocytes by regulating Beclin-1 expression through epigenetic modulation. Toxicology. 2018 Dec 1;410:49-58. [Content Brief]
- [7]. Habas K, et al. Diethylstilbestrol induces oxidative DNA damage, resulting in apoptosis of spermatogonial stem cells in vitro. Toxicology. 2017 May 1;382:117-121. [Content Brief]
- [8]. Wang Y, et al. Diethylstilbestrol inhibits human and rat 11β-hydroxysteroid dehydrogenase 2. Endocr Connect. 2019 Jul;8(7):1061-1069. [Content Brief]
