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    Autophagy
    Apoptosis
  2. Progesterone Receptor
    Autophagy
    Apoptosis
  3. Dienogest

Dienogest (Synonyms: STS 557)

Cat. No.: HY-B0084 Purity: 99.83%
Handling Instructions

Dienogest(STS-557) is a specific progesterone receptor agonist with potent oral endometrial activity and is used in the treatment of endometriosis.

For research use only. We do not sell to patients.

Dienogest Chemical Structure

Dienogest Chemical Structure

CAS No. : 65928-58-7

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10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
10 mg USD 50 In-stock
Estimated Time of Arrival: December 31
50 mg USD 90 In-stock
Estimated Time of Arrival: December 31
100 mg USD 150 In-stock
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Description

Dienogest(STS-557) is a specific progesterone receptor agonist with potent oral endometrial activity and is used in the treatment of endometriosis. Target: progesterone receptor agonist Dienogest is an orally active synthetic progesterone (or progestin). It is available for use as an oral contraceptive in combination with ethinylestradiol. It has antiandrogenic activity and as a result can improve androgenic symptoms. It is a non-ethinylated progestin which is structurally related to testosterone [1]. Complete sperm suppression was observed in rats sacrificed either 60 or 90 days after dienogest (DNG)+ testosterone undecanoate (TU) administration, for two injections at 45-day interval. The neutral α-glucosidase activity in these treated rats remained in the normal range. Germ cell loss due to apoptosis was frequently observed both after 60 or 90 days of combination treatment. Significant decline in serum gonadotropin and testosterone, both serum and intratesticular levels, were observed in the treated rats. Following stoppage of treatment (given at 45-day interval) after two (0 and 45 days) or three injections (0, 45 and 90 days), complete restoration of spermatogenesis was observed by 120 and 165 days, respectively [2]. Clinical indications: Adenomyosis; Endometriosis FDA Approved Date: 1995 Toxicity: weight gain; increased blood pressure; breast tenderness and nausea

Clinical Trial
Molecular Weight

311.42

Formula

C₂₀H₂₅NO₂

CAS No.
SMILES

C[[email protected]@]12[[email protected]](O)(CC#N)CC[[email protected]@]1([H])[[email protected]]3([H])CCC4=CC(CCC4=C3CC2)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (80.28 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2111 mL 16.0555 mL 32.1110 mL
5 mM 0.6422 mL 3.2111 mL 6.4222 mL
10 mM 0.3211 mL 1.6055 mL 3.2111 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (8.03 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (8.03 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (8.03 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.83%

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Keywords:

DienogestSTS 557STS557STS-557Progesterone ReceptorAutophagyApoptosisNR3C3Inhibitorinhibitorinhibit

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