Tyk2 Degrader
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TYD-68
0 ImagesTYD-68 is a CRBN-recruiting TYK2 PROTAC degrader with a DC50 of 0.42 nM, and displays selectivity against JAK1/JAK2-dependent signaling pathways. TYD-68 inhibits TYK2-mediated signaling, exerts therapeutic efficacy in murine psoriasis models, reduces PASI scores, downregulates TYK2 protein levels and decreases the secretion of proinflammatory cytokines, TYD-68 can be used for the study of psoriasis and other TYK2-driven autoimmune diseases.
