3110703-72-2
3110703-72-2
Chemical Structure
TYD-68
- CAS No.: 3110703-72-2
- Formula:C43H40FN11O7
- Molecular Weight:841.85
InChIKey: NKSVQPQJZWJRLO-UHFFFAOYSA-N
SMILES: COC1=C(C=CC=C1C2=NC=C(C=N2)F)NC3=CC(NC4=CC=C(C=N4)C(NC5CCC(CC5)NC6=CC7=C(C=C6)C(N(C7=O)C8C(NC(CC8)=O)=O)=O)=O)=NC=C3C(NC)=O
Biological Activity: TYD-68 is a highly efficient and selective CRBN-recruited TYK2 PROTAC degrader with a DC50 value of 0.42 nM. TYD-68 significantly inhibits IL-12 and IFN-α-induced STAT4 and STAT1 phosphorylation, thereby blocking TYK2-dependent signaling pathways. TYD-68 can be used in the study of psoriasis[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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TYD-68 | 99.54% | TYD-68 is a highly efficient and selective CRBN-recruited TYK2 PROTAC degrader with a DC50 value of 0.42 nM. TYD-68 significantly inhibits IL-12 and IFN-α-induced STAT4 and STAT1 phosphorylation, thereby blocking TYK2-dependent signaling pathways. TYD-68 can be used in the study of psoriasis. | ||||||||||||||||||||
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References
Keywords
